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Qing Yin Wang
Researcher at Novartis Institute for Tropical Diseases
Publications - 25
Citations - 2384
Qing Yin Wang is an academic researcher from Novartis Institute for Tropical Diseases. The author has contributed to research in topics: Dengue virus & Virus. The author has an hindex of 22, co-authored 25 publications receiving 2104 citations. Previous affiliations of Qing Yin Wang include Novartis.
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Journal ArticleDOI
An adenosine nucleoside inhibitor of dengue virus
Zheng Yin,Zheng Yin,Yen Liang Chen,Wouter Schul,Qing Yin Wang,Feng Gu,Jeyaraj Duraiswamy,Ravinder Reddy Kondreddi,Pornwaratt Niyomrattanakit,Suresh B. Lakshminarayana,Anne Goh,Hao Ying Xu,Wei Liu,Boping Liu,Joanne Y.H. Lim,Chuan Young Ng,Min Qing,Chin Chin Lim,Andy Yip,Gang Wang,Wai Ling Chan,Hui Pen Tan,Kai Lin,Bo Zhang,Gang Zou,Kristen A. Bernard,Christine E. Garrett,Karen Beltz,Min Dong,Margaret Weaver,Handan He,Arkadius Pichota,Véronique Dartois,Thomas H. Keller,Pei Yong Shi +34 more
TL;DR: The results have proved the concept that a nucleoside inhibitor could be developed for potential treatment of flavivirus infections and suppressed peak viremia, reduced cytokine elevation, and completely prevented the infected mice from death.
Journal ArticleDOI
Ten years of dengue drug discovery: Progress and prospects
Siew Pheng Lim,Qing Yin Wang,Christian G. Noble,Yen Liang Chen,Hongping Dong,Bin Zou,Fumiaki Yokokawa,Shahul Nilar,Paul Smith,David Beer,Julien Lescar,Pei Yong Shi +11 more
TL;DR: The knowledge accumulated during the past decade has provided a better rationale for ongoing dengue drug discovery and it is optimistic that this continuous, concerted effort will lead to an effective d Dengue therapy.
Journal ArticleDOI
Strategies for development of Dengue virus inhibitors.
Christian G. Noble,Yen Liang Chen,Hongping Dong,Feng Gu,Siew Pheng Lim,Wouter Schul,Qing Yin Wang,Pei Yong Shi +7 more
TL;DR: The strategies discussed in this report should be applicable to antiviral development of other viruses, including dengue virus and other flaviviruses.
Journal ArticleDOI
Dengue virus serotype infection specifies the activation of the unfolded protein response
TL;DR: Evidence is provided that Dengue infection induces and regulates the three branches of the UPR signaling cascades, a basis for the understanding of the viral regulation and conditions beneficial to the viral infection.
Journal ArticleDOI
Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis
Qing Yin Wang,Bushell Simon,Min Qing,Hao Ying Xu,Aurelio Bonavia,Sandra Nunes,Jing Zhou,Mee Kian Poh,Paola Florez de Sessions,Pornwaratt Niyomrattanakit,Hongping Dong,Keith Hoffmaster,Anne Goh,Shahul Nilar,Wouter Schul,Susan Jones,Laura D. Kramer,Teresa Compton,Pei Yong Shi +18 more
TL;DR: A novel antiviral compound (NITD-982) that inhibits host dihydroorotate dehydrogenase (DHODH), an enzyme required for pyrimidine biosynthesis is reported, demonstrating that the compound inhibits DENV through depleting the intracellular pyridine pool.