G
Guanghou Shui
Researcher at Chinese Academy of Sciences
Publications - 243
Citations - 15804
Guanghou Shui is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Lipid metabolism & Medicine. The author has an hindex of 58, co-authored 207 publications receiving 12542 citations. Previous affiliations of Guanghou Shui include National University of Singapore & Agency for Science, Technology and Research.
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Journal ArticleDOI
An investigation of antioxidant capacity of fruits in Singapore markets
Lai Peng Leong,Guanghou Shui +1 more
TL;DR: In this paper, the contribution of l-ascorbic acid (AA) to the total antioxidant activity of fruits was investigated by using RP-HPLC, which measured the change of absorbance of the free radical solution at 414 nm in the test reaction mixture following addition of the fruit extract, as compared with AA.
Journal ArticleDOI
Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase
You-Tong Wu,Hui-Ling Tan,Guanghou Shui,Chantal Bauvy,Qing Huang,Markus R. Wenk,Choon Nam Ong,Patrice Codogno,Han-Ming Shen,Han-Ming Shen +9 more
TL;DR: To their surprise, 3-MA is found to promote autophagy flux when treated under nutrient-rich conditions with a prolonged period of treatment, whereas it is still capable of suppressing starvation-induced autophagosomes or lysosomal function.
Journal ArticleDOI
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
Long N. Nguyen,Dongliang Ma,Guanghou Shui,Peiyan Wong,Amaury Cazenave-Gassiot,Xiao-Dong Zhang,Markus R. Wenk,Eyleen L. K. Goh,David L. Silver +8 more
TL;DR: This work identifies a member of the major facilitator superfamily—Mfsd2a (previously an orphan transporter)—as the major transporter for DHA uptake into brain and reveals an unexpected essential physiological role of plasma-derived LPCs in brain growth and function.
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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
William L. Holland,Benjamin T. Bikman,Liping Wang,Guan Yuguang,Katherine M. Sargent,Sarada Bulchand,Trina A. Knotts,Guanghou Shui,Deborah J. Clegg,Markus R. Wenk,Michael J. Pagliassotti,Philipp E. Scherer,Scott A. Summers,Scott A. Summers,Scott A. Summers +14 more
TL;DR: It is shown here that TLR4 is an upstream signaling component required for saturated fatty acid-induced ceramide biosynthesis, and that sphingolipids such as ceramide might be key components of the signaling networks that link lipid-induced inflammatory pathways to the antagonism of insulin action that contributes to diabetes.
Journal ArticleDOI
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.
Robin B. Chan,Tiago Gil Oliveira,Etty Cortes,Lawrence S. Honig,Karen Duff,Scott A. Small,Markus R. Wenk,Guanghou Shui,Gilbert Di Paolo +8 more
TL;DR: In this paper, a system-based approach was employed to determine the lipidome of brain tissues affected by Alzheimer disease using liquid chromatography-mass spectrometry to profile extracts from the prefrontal cortex, entorhinal cortex, and cerebellum of late-onset AD patients.