Anirban Ghosh

TL;DR: The expression of p47 through alternative splicing of the p53 gene resulting in the expression of a novel p53 mRNA encodes an N-terminally deleted isoform of p53 termed p47, which has a major influence over p53 activity at least in part through controlling p53 ubiquitination and cell localization.

TL;DR: It is shown that immunization of mice with recombinant A2 protein conferred significant protection against challenge infection with Leishmania donovani, and A2 represents a potential antigen for protection against infection with L.Donovani and VL.

TL;DR: It is demonstrated that although L. major contains A2 gene regulatory sequences, the multiple repeats that exist in L. donovani A2 protein coding regions are absent, and the remaining corresponding A2 sequences appear to represent non-expressed pseudogenes, and it was possible to restore amastigote-specific A2 expression to L.major, confirming that A2 regulatory sequences remain functional inL.

TL;DR: High‐resolution structural information is provided on the interaction between indolicidin and DNA, which will be beneficial for the design of novel therapeutic antibiotics based on peptide scaffolds.

TL;DR: VG16KRKP, a non-toxic and non-hemolytic analogue of VG16, shows significant antimicrobial activity against Gram-negative E. coli and plant pathogens X. oryzae and X. campestris, as well as against human fungal pathogens C. albicans and C. grubii.