M
Megan D. Lenardon
Researcher at University of Aberdeen
Publications - 25
Citations - 2397
Megan D. Lenardon is an academic researcher from University of Aberdeen. The author has contributed to research in topics: Candida albicans & Chitin. The author has an hindex of 17, co-authored 23 publications receiving 2041 citations. Previous affiliations of Megan D. Lenardon include University of New South Wales.
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Journal ArticleDOI
Stimulation of chitin synthesis rescues Candida albicans from echinocandins.
Louise A. Walker,Carol A. Munro,Irene de Bruijn,Megan D. Lenardon,Alastair D. McKinnon,Neil A. R. Gow +5 more
TL;DR: Echinocandins and chitin synthase inhibitors synergized strongly, highlighting the potential for combination therapies with greatly enhanced cidal activity.
Journal ArticleDOI
Chitin synthesis and fungal pathogenesis
TL;DR: This review summarises latest advances in the analysis of chitin synthesis regulation in the context of fungal pathogenesis and describes how this plays a role in the activation and attenuation of immune responses to fungi and other chitIn-containing parasites.
Journal ArticleDOI
The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans
Carol A. Munro,Serena Selvaggini,Irene de Bruijn,Louise A. Walker,Megan D. Lenardon,Bertus Gerssen,Sarah Amelia Milne,Alistair J. P. Brown,Neil A. R. Gow +8 more
TL;DR: At least three pathways co‐ordinated by the PKC, HOG MAP kinase and Ca2+/calcineurin signalling pathways co-ordinated chitin synthesis and activation of chit in synthesis operates at both transcriptional and post‐transcriptional levels.
Journal ArticleDOI
Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation
Jeanette Wagener,R. K. Subbarao Malireddi,Megan D. Lenardon,Martin Köberle,Simon Vautier,Donna M. MacCallum,Tilo Biedermann,Martin Schaller,Mihai G. Netea,Thirumala-Devi Kanneganti,Gordon D. Brown,Alistair J. P. Brown,Neil A. R. Gow +12 more
TL;DR: It is shown that three immune cell receptors– the mannose receptor, NOD2 and TLR9 recognise chitin and act together to mediate an anti-inflammatory response via secretion of the cytokine IL-10, which may prevent inflammation-based damage during fungal infection and restore immune balance after an infection has been cleared.
Journal ArticleDOI
The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
Shih-Chin Cheng,Frank L. van de Veerdonk,Megan D. Lenardon,Monique Stoffels,Theo S. Plantinga,Sanne P. Smeekens,Lisa Rizzetto,Liliane Mukaremera,Kanya Preechasuth,Duccio Cavalieri,Thirumala-Devi Kanneganti,Jos W. M. van der Meer,Bart Jan Kullberg,Leo A. B. Joosten,Neil A. R. Gow,Mihai G. Netea +15 more
TL;DR: The dectin‐1/inflammasome pathway is defined as the mechanism that enables the host immune system to mount a protective Th17 response and distinguish between colonization and tissue invasion by C. albicans.