Megumi Eguchi

TL;DR: CUBIC enables time-course expression profiling of whole adult brains with single-cell resolution and develops a whole-brain cell-nuclear counterstaining protocol and a computational image analysis pipeline that enable the visualization and quantification of neural activities induced by environmental stimulation.

TL;DR: Using in vivo longitudinal multiphoton imaging, orchestrated activity-dependent expression of Arc is found in the mouse extrastriate visual cortex in response to a structured visual stimulation, and disruption in Arc patterns reveals plaque-associated interference with neural network integration.

TL;DR: Transgenic mice with high level expression of the reporter gene driven by the Arc gene promoter, which is activated in association with various brain functions, are produced, and it is found that the cingulate cortex was strongly activated by light stimuli.

TL;DR: The results obtained from the Barnes maze suggest that the usage of the right hippocampus improves the accuracy of spatial memory, and performance of non‐spatial yet hippocampus‐dependent tasks (e.g. fear conditioning) was not influenced by the laterality of the hippocampus.

TL;DR: Key insights are suggested for the neural circuits underlying spatial mnemonic processing during a working memory task and the involvement of α-CaMKII in the proper maturation and integration of DG neurons into these circuits are suggested.