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Shun Yamaguchi
Researcher at Gifu University
Publications - Â 50
Citations - Â 6847
Shun Yamaguchi is an academic researcher from Gifu University. The author has contributed to research in topics: Suprachiasmatic nucleus & Circadian rhythm. The author has an hindex of 29, co-authored 48 publications receiving 6181 citations. Previous affiliations of Shun Yamaguchi include Kobe University & Kyoto University.
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Journal ArticleDOI
Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis
Etsuo A. Susaki,Kazuki Tainaka,Kazuki Tainaka,Dimitri Perrin,Fumiaki Kishino,Takehiro Tawara,Tomonobu M. Watanabe,Chihiro Yokoyama,Hirotaka Onoe,Megumi Eguchi,Shun Yamaguchi,Shun Yamaguchi,Takaya Abe,Hiroshi Kiyonari,Yoshihiro Shimizu,Atsushi Miyawaki,Hideo Yokota,Hiroki R. Ueda +17 more
TL;DR: CUBIC enables time-course expression profiling of whole adult brains with single-cell resolution and develops a whole-brain cell-nuclear counterstaining protocol and a computational image analysis pipeline that enable the visualization and quantification of neural activities induced by environmental stimulation.
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Control mechanism of the circadian clock for timing of cell division in vivo.
Takuya Matsuo,Shun Yamaguchi,Shun Yamaguchi,Shigeru Mitsui,Shigeru Mitsui,Aki Emi,Aki Emi,Fukuko Shimoda,Fukuko Shimoda,Hitoshi Okamura,Hitoshi Okamura +10 more
TL;DR: It is shown in the regenerating liver (of mice) that the circadian clock controls the expression of cell cycle–related genes that in turn modulate theexpression of active Cyclin B1-Cdc2 kinase, a key regulator of mitosis.
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Synchronization of cellular clocks in the suprachiasmatic nucleus.
Shun Yamaguchi,Hiromi Isejima,Hiromi Isejima,Takuya Matsuo,Takuya Matsuo,Ryusuke Okura,Kazuhiro Yagita,Masaki Kobayashi,Hitoshi Okamura +8 more
TL;DR: Real-time analysis of gene expression was used to show synchronized rhythms of clock gene transcription across hundreds of neurons within the mammalian SCN in organotypic slice culture, and Na+-dependent action potentials contributed to establishing cellular synchrony and maintaining spontaneous oscillation across the SCN.
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Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock.
Hitoshi Okamura,Shigeru Miyake,Yasuo Sumi,Shun Yamaguchi,Akira Yasui,Manja Muijtjens,Jan H.J. Hoeijmakers,Gijsbertus T. J. van der Horst +7 more
TL;DR: These findings indicate that the biological clock is eliminated in the absence of both mCRY1 and m CRY2 and support the idea that mammalian CRY proteins act in the negative limb of the circadian feedback loop.
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Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism
TL;DR: It is shown that the phase of e4bp4 mRNA rhythm is opposite to that of the dbp, hlf, and tef rhythms in the suprachiasmatic nucleus (SCN), the mammalian circadian center, and the liver, and that the protein levels of E4BP4 and DBP fluctuate in almost the opposite phase.