M
Megumi Matsumoto
Researcher at Sapporo Medical University
Publications - 21
Citations - 606
Megumi Matsumoto is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Insulin resistance & Population. The author has an hindex of 14, co-authored 20 publications receiving 408 citations.
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Journal ArticleDOI
Local Production of Fatty Acid–Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis
Masato Furuhashi,Takahiro Fuseya,Masaki Murata,Kyoko Hoshina,Shutaro Ishimura,Tomohiro Mita,Yuki Watanabe,Akina Omori,Megumi Matsumoto,Takeshi Sugaya,Tsuyoshi Oikawa,Junichi Nishida,Nobuaki Kokubu,Marenao Tanaka,Norihito Moniwa,Hideaki Yoshida,Norimasa Sawada,Kazuaki Shimamoto,Tetsuji Miura +18 more
TL;DR: FABP4 locally produced by epicardial/perivascular fat and macrophages in vascular plaques contributes to the development of coronary atherosclerosis.
Journal ArticleDOI
Plasma Xanthine Oxidoreductase Activity as a Novel Biomarker of Metabolic Disorders in a General Population.
Masato Furuhashi,Megumi Matsumoto,Marenao Tanaka,Norihito Moniwa,Takayo Murase,Takashi Nakamura,Hirofumi Ohnishi,Shigeyuki Saitoh,Shigeyuki Saitoh,Kazuaki Shimamoto,Tetsuji Miura +10 more
TL;DR: Plasma XOR activity is a novel biomarker of metabolic disorders in a general population and was significantly higher in males than in females, and habitual smoking was associated with elevation of activity.
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Reduction of serum FABP4 level by sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes mellitus
Masato Furuhashi,Shinya Hiramitsu,Tomohiro Mita,Takahiro Fuseya,Shutaro Ishimura,Akina Omori,Megumi Matsumoto,Yuki Watanabe,Kyoko Hoshina,Marenao Tanaka,Norihito Moniwa,Hideaki Yoshida,Junnichi Ishii,Tetsuji Miura +13 more
TL;DR: Sitagliptin decreases serum FABP4 level, at least in part, via reduction in the expression and consecutive secretion of FABp4 in adipocytes by direct inhibition of DPP-4.
Journal ArticleDOI
Ectopic Fatty Acid-Binding Protein 4 Expression in the Vascular Endothelium is Involved in Neointima Formation After Vascular Injury.
Takahiro Fuseya,Masato Furuhashi,Megumi Matsumoto,Yuki Watanabe,Kyoko Hoshina,Tomohiro Mita,Shutaro Ishimura,Marenao Tanaka,Tetsuji Miura +8 more
TL;DR: Ectopic expression and secretion of FABP4 in vascular endothelial cells contribute to neointima formation after vascular injury and suppression of ectopic FABp4 in the vascular endothelium would be a novel strategy against post‐angioplasty vascular restenosis.
Journal ArticleDOI
Reduction of circulating FABP4 level by treatment with omega-3 fatty acid ethyl esters
Masato Furuhashi,Shinya Hiramitsu,Tomohiro Mita,Akina Omori,Takahiro Fuseya,Shutaro Ishimura,Yuki Watanabe,Kyoko Hoshina,Megumi Matsumoto,Marenao Tanaka,Norihito Moniwa,Hideaki Yoshida,Junnichi Ishii,Tetsuji Miura +13 more
TL;DR: Omega-3 fatty acids decrease circulating FABP4 level, possibly by reducing expression and consecutive secretion of FABp4 in adipocytes, by treatment with EPA or DHA.