M
Mehdi Khoshneviszadeh
Researcher at Shiraz University of Medical Sciences
Publications - 101
Citations - 1896
Mehdi Khoshneviszadeh is an academic researcher from Shiraz University of Medical Sciences. The author has contributed to research in topics: Tyrosinase & Chemistry. The author has an hindex of 21, co-authored 88 publications receiving 1331 citations. Previous affiliations of Mehdi Khoshneviszadeh include Tehran University of Medical Sciences & Shiraz University.
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Journal ArticleDOI
Dihydropyridines: evaluation of their current and future pharmacological applications
TL;DR: It might be possible for the DHP motif to serve as a scaffold for other pharmacological applications, particularly as antimycobacterial and anticonvulsant agents.
Journal ArticleDOI
Synthesis and biological evaluation of some new 1,4-dihydropyridines containing different ester substitute and diethyl carbamoyl group as anti-tubercular agents.
Mehdi Khoshneviszadeh,Najmeh Edraki,Katayoun Javidnia,Abdolvahab Alborzi,Bahman Pourabbas,Jalal Mardaneh,Ramin Miri +6 more
TL;DR: New derivatives of 1,4-dihydropyridines in which different alkyl and aryl esters and diethyl carbamoyl are substituted in C-3 and C-5 of the DHP ring are synthesized, indicating that the compounds containing aromatic esters are more potent thanAlkyl ones.
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Design, synthesis and biological evaluation of novel anti-cytokine 1,2,4-triazine derivatives
Mehdi Khoshneviszadeh,Mohammad Hossein Ghahremani,Alireza Foroumadi,Alireza Foroumadi,Ramin Miri,Omidreza Firuzi,Armin Madadkar-Sobhani,Najmeh Edraki,Najmeh Edraki,Maliheh Parsa,Abbas Shafiee +10 more
TL;DR: The results of Western blotting demonstrated that the anti-cytokine potential of compound 7l is mainly mediated through the inhibition of p38 MAPK signaling pathway, and might be helpful for the design and synthesis of novel scaffold toward the development of new therapeutic agent to fight against inflammatory diseases.
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Multifunctional iminochromene-2H-carboxamide derivatives containing different aminomethylene triazole with BACE1 inhibitory, neuroprotective and metal chelating properties targeting Alzheimer's disease.
Aida Iraji,Omidreza Firuzi,Mehdi Khoshneviszadeh,Marjan Tavakkoli,Mohammad Mahdavi,Hamid Nadri,Najmeh Edraki,Ramin Miri +7 more
TL;DR: A new family of iminochromene carboxamides containing different aminomethylene triazole derivatives showing promising activity as neuroprotective agents against AD is developed and proposed that introduction of a phthalimide substitute on the Triazole ring shown to be interesting multifunctional lead compound worthy of further study.
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Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations.
Maryam Gholampour,Sara Ranjbar,Najmeh Edraki,Maryam Mohabbati,Omidreza Firuzi,Mehdi Khoshneviszadeh +5 more
TL;DR: Flow cytometric analysis revealed that compounds 3, 6f and 6h arrested cell cycle at G0/G1 phase in MCF-7 cells, therefore, synthesized aminonaphthoquinone-1,2,3-triazole derivatives can be introduced as promising molecules for further development as potential anticancer agents.