M
Mehdi Totonchi
Researcher at Royan Institute
Publications - 131
Citations - 2536
Mehdi Totonchi is an academic researcher from Royan Institute. The author has contributed to research in topics: Embryonic stem cell & Medicine. The author has an hindex of 23, co-authored 109 publications receiving 1817 citations. Previous affiliations of Mehdi Totonchi include Tehran University of Medical Sciences & Academic Center for Education, Culture and Research.
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Journal ArticleDOI
Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy
A. Ghavamzadeh,Kamran Alimoghaddam,Seyed H. Ghaffari,S. Rostami,Mohamad Jahani,Rohollah Hosseini,A. Mossavi,Eissa Baybordi,A. Khodabadeh,Massoud Iravani,Babak Bahar,Yousef Mortazavi,Mehdi Totonchi,Nasser Aghdami +13 more
TL;DR: Arsenic trioxide is effective as first-line treatment for APL and results of arsenic trioxide combination therapy with chemotherapy/ATRA requires further study.
Journal ArticleDOI
Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells
Arefeh Ghodsizadeh,Adeleh Taei,Mehdi Totonchi,Ali Seifinejad,Hamid Gourabi,Behshad Pournasr,Nasser Aghdami,Reza Malekzadeh,Navid Almadani,Ghasem Hosseini Salekdeh,Hossein Baharvand +10 more
TL;DR: The derivation of iPSCs by the retroviral transduction of Yamanaka's factors in serum and feeder-free culture conditions from liver-specific patients with tyrosinemia, glycogen storage disease, progressive familial hereditary cholestasis and two siblings with Crigler-Najjar syndrome is reported.
Proceedings ArticleDOI
Automatic white blood cell classification using pre-trained deep learning models: ResNet and Inception
TL;DR: This work considers the problem of pre-processing and supervised classification of white blood cells into their four primary types including Neutrophils, Eosinophils, Lymphocytes, and Monocytes using a consecutive proposed deep learning framework and seeks to determine a fast, accurate mechanism for classification.
Journal ArticleDOI
Feeder- and serum-free establishment and expansion of human induced pluripotent stem cells
Mehdi Totonchi,Adeleh Taei,Ali Seifinejad,Mohammadsharif Tabebordbar,Hassan Rassouli,Ali Farrokhi,Hamid Gourabi,Nasser Aghdami,Ghasem Hosseini-Salekdeh,Hossein Baharvand +9 more
TL;DR: A novel establishment and maintenance culture technique that uses human dermal fibroblasts to generate hiPSCs by introducing four factors, Klf4, Oct4, Sox2, and c-Myc under serum- and feeder-independent conditions is described.
Journal ArticleDOI
Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.
Mohammad Pakzad,Mehdi Totonchi,Adeleh Taei,Ali Seifinejad,Seyedeh-Nafiseh Hassani,Hossein Baharvand,Hossein Baharvand +6 more
TL;DR: Results show that addition of ROCKi in the extracellular matrix can increase the plating efficiency of hESCs and hiPSCs during passaging of clusters due not only to an anti-apoptotic effect, but also to an increase in the ECM-cells interaction.