M
Mei-Ping Kung
Researcher at University of Pennsylvania
Publications - 207
Citations - 10465
Mei-Ping Kung is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Ligand (biochemistry) & In vivo. The author has an hindex of 58, co-authored 207 publications receiving 10135 citations. Previous affiliations of Mei-Ping Kung include University of Florida & Chang Gung University.
Papers
More filters
Journal ArticleDOI
Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
Christopher C. Rowe,Uwe Ackerman,William J Browne,Rachel S. Mulligan,Kerryn L Pike,Graeme O'Keefe,H. J. Tochon-Danguy,Gordon Chan,Salvatore U Berlangieri,Gareth Jones,Kerryn L Dickinson-Rowe,H Kung,Wei Zhang,Mei-Ping Kung,Daniel Skovronsky,Thomas Dyrks,Gerhard Holl,Sabine Krause,Matthias Friebe,Lutz Lehman,Stefanie Lindemann,Ludger Dinkelborg,Colin L. Masters,Victor L. Villemagne +23 more
TL;DR: F-BAY94-9172 PET discriminates between AD and FTLD or healthy controls and might facilitate integration of Abeta imaging into clinical practice.
Journal ArticleDOI
In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET.
Nicolaas Paul L.G. Verhoeff,Alan A. Wilson,Shinichiro Takeshita,Liat Trop,Doug Hussey,Kernjit Singh,Hank F. Kung,Mei-Ping Kung,Sylvain Houle +8 more
TL;DR: Preliminary PET data indicate that [11C]SB-13 is an effective PET tracer for fibrillar Abeta imaging in vivo, with similar performance as [ 11C]PIB, and the two radiotracers demonstrated similar binding properties.
Journal ArticleDOI
F-18 Polyethyleneglycol stilbenes as PET imaging agents targeting Aβ aggregates in the brain
TL;DR: The preliminary results strongly suggest 18F-labeled polyethyleneglycol (PEG)-stilbene derivatives are suitable candidates as Abeta plaque imaging agents for studying patients with Alzheimer's disease.
Journal ArticleDOI
Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates
Zhi-Ping Zhuang,Mei-Ping Kung,Catherine Hou,Daniel M. Skovronsky,Tamar L. Gur,Karl Plössl,John Q. Trojanowski,Virginia M.-Y. Lee,Hank F. Kung +8 more
TL;DR: It is reported for the first time that small molecule-based radiodiodinated ligands, showing selective binding to Abeta aggregates, cross the intact blood-brain barrier by simple diffusion.
Journal ArticleDOI
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
Daniel M. Skovronsky,Bin Zhang,Mei-Ping Kung,Hank F. Kung,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: BSB has the following properties essential for a probe that can detect SPs in vivo: permeates living cells in culture and binds specifically to intracellular Aβ aggregates, and crosses the blood–brain barrier and labels numerous AD-like SPs throughout the brain of the transgenic mice after i.v. injection.