Catherine Hou

TL;DR: The data suggests that [123I]16(IMPY) may be useful for imaging A beta aggregates in patients with Alzheimer's disease.

TL;DR: The preliminary results strongly suggest 18F-labeled polyethyleneglycol (PEG)-stilbene derivatives are suitable candidates as Abeta plaque imaging agents for studying patients with Alzheimer's disease.

TL;DR: It is reported for the first time that small molecule-based radiodiodinated ligands, showing selective binding to Abeta aggregates, cross the intact blood-brain barrier by simple diffusion.

TL;DR: It is shown that the nuclear receptor Rev-erbα, a powerful transcriptional repressor, links circadian and thermogenic networks through the regulation of brown adipose tissue (BAT) function and acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands.

TL;DR: It is suggested that radioiodinated IMPY demonstrates desirable characteristics for in vivo labeling of Abeta plaques and it may be useful as a molecular imaging agent to study amyloidogenesis in the brain of living AD patients.