Mei Zhang

TL;DR: Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur and present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression.

TL;DR: In vivo experiments showed that tFNAs facilitated diabetic wound healing by accelerating vascularization, epithelialization, collagen deposition and collagen alignment, and could protect endothelial cell function, reduce inflammation and impede oxidative damage through their antioxidant activity via the Akt/Nrf2/HO-1 signaling pathway.

TL;DR: This is the first study to demonstrate that nanophase materials with the biological features of nucleic acids accelerate the healing of cutaneous wounds and reduce scarring, which indicates the potential application of tFNAs in skin tissue regeneration.

TL;DR: Tetrahedral framework nucleic acids could reduce the production of reactive oxygen species in cells and protect the cells from oxidative stress by regulating intracellular oxidation-related enzymes and tFNAs could simultaneously improve oxidative stress-induced apoptosis significantly via affecting the expression of apoptosis-related proteins.

TL;DR: Tetrahedral DNA nanostructures can significantly decrease oxidative damage and apoptosis by limiting the overexpression of ROS, along with effecting the expression of apoptosis-related proteins, which makes them a potential therapeutic drug for MIRI.