M
Meihui Pan
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 10
Citations - 995
Meihui Pan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Endoplasmic reticulum & Secretion. The author has an hindex of 10, co-authored 10 publications receiving 952 citations. Previous affiliations of Meihui Pan include Rockefeller University & Columbia University.
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Journal ArticleDOI
Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
Meihui Pan,Arthur I. Cederbaum,Yuan-Li Zhang,Henry N. Ginsberg,Kevin Jon Williams,Edward A. Fisher +5 more
TL;DR: A novel link between lipid peroxidation and oxidant stress with ApoB100 degradation via PERPP is established, and may be relevant to the hypolipidemic actions of dietary PUFAs, the basal regulation of ApOB100 secretion, and hyperlipidemias arising from Apo B100 overproduction.
Journal ArticleDOI
The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways.
Edward A. Fisher,Meihui Pan,Xiaoli Chen,Xinye Wu,Hongxing Wang,Jamil Haris,Janet D. Sparks,Kevin Jon Williams +7 more
TL;DR: F nascent apoB is subject to ER-associated degradation, re-uptake, and a third distinct degradative pathway that appears to target lipoproteins after considerable assembly and involves a post-ER compartment and PI3K signaling.
Journal ArticleDOI
Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control
Meihui Pan,Vatsala Maitin,Sajesh Parathath,Ursula Andreo,Sharron X. Lin,Carly St. Germain,Zemin Yao,Frederick R. Maxfield,Kevin Jon Williams,Edward A. Fisher +9 more
TL;DR: Secretory control via PERPP/autophagosomes is likely a key component of normal and pathologic regulation of plasma apoB levels, as well as a means for remarkably late-stage quality control of a secreted protein.
Journal ArticleDOI
Phospholipid Transfer Protein Deficiency Impairs Apolipoprotein-B Secretion from Hepatocytes by Stimulating a Proteolytic Pathway through a Relative Deficiency of Vitamin E and an Increase in Intracellular Oxidants *
Xian-Cheng Jiang,Zhiqiang Li,Ruijie Liu,Xiao Ping Yang,Meihui Pan,Laurent Lagrost,Edward A. Fisher,Kevin Jon Williams +7 more
TL;DR: PLTP deficiency decreases liver vitamin E content, increases hepatic oxidant tone, and substantially enhances ROS-dependent destruction of newly synthesized apoB via a post-ER process, likely to be broadly relevant to hepatic apo B secretory control in vivo.