M
Meilan Liu
Researcher at University of Michigan
Publications - 42
Citations - 2512
Meilan Liu is an academic researcher from University of Michigan. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 17, co-authored 33 publications receiving 2194 citations.
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Journal ArticleDOI
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
Sanjeev Shangary,Dongguang Qin,Donna McEachern,Meilan Liu,Rebecca Miller,Su Qiu,Zaneta Nikolovska-Coleska,Ke Ding,Guoping Wang,Jianyong Chen,Denzil Bernard,Jian Zhang,Yipin Lu,Qingyang Gu,Rajal B. Shah,Kenneth J. Pienta,Xiaolan Ling,Sanmao Kang,Ming Guo,Yi Sun,Dajun Yang,Shaomeng Wang +21 more
TL;DR: MI-219 stimulates rapid but transient p53 activation in established tumor xenograft tissues, resulting in inhibition of cell proliferation, induction of apoptosis, and complete tumor growth inhibition.
Journal ArticleDOI
PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma
J. Chad Brenner,Felix Y. Feng,Sumin Han,Sonam Patel,Siddharth V. Goyal,Laura M. Bou-Maroun,Meilan Liu,Robert J. Lonigro,John R. Prensner,Scott A. Tomlins,Arul M. Chinnaiyan +10 more
TL;DR: These findings offer a strong preclinical rationale to target the EWS-FLI1:PARP1 intersection as a therapeutic strategy to improve the treatment of Ewing's sarcoma family of tumors.
Journal ArticleDOI
Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer.
Liang Xu,Dajun Yang,Shaomeng Wang,Wenhua Tang,Meilan Liu,Mary A. Davis,Jianyong Chen,James M. Rae,Theodore Lawrence,Marc E. Lippman +9 more
TL;DR: The results show that the natural polyphenol inhibitor of Bcl-2/Bcl-xL, (-)-gossypol, can radiosensitize prostate cancer in vitro and in vivo without augmenting toxicity.
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Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
Yang Meng,Wenhua Tang,Yao Dai,Xiaoqing Wu,Meilan Liu,Qing Ji,Min Ji,Kenneth J. Pienta,Theodore Lawrence,Liang Xu +9 more
TL;DR: Data suggest that (-)-gossypol significantly enhances the antitumor activity of chemotherapy in vitro and in vivo, representing a promising new regime for the treatment of human hormone-refractory prostate cancer with Bcl-2/Bcl-xL/Mcl-1 overexpression.
Journal ArticleDOI
Structure-based design of potent, conformationally constrained Smac mimetics
Haiying Sun,Zaneta Nikolovska-Coleska,Chao Yie Yang,Liang Xu,Meilan Liu,York Tomita,Hongguang Pan,Yoshiko Yoshioka,Krzysztof Krajewski,Peter P. Roller,Shaomeng Wang +10 more
TL;DR: These potent Smac mimetics can serve as powerful chemical and pharmacological tools to further elucidate the role of Smac and its cellular binding partners in apoptosis regulation and may be developed as a new class of anti-cancer drugs.