M
Melanie Alufandika-Moyo
Researcher at Dignitas International
Publications - 5
Citations - 227
Melanie Alufandika-Moyo is an academic researcher from Dignitas International. The author has contributed to research in topics: Tuberculosis & Randomized controlled trial. The author has an hindex of 5, co-authored 5 publications receiving 160 citations. Previous affiliations of Melanie Alufandika-Moyo include Malawi-Liverpool-Wellcome Trust Clinical Research Programme.
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Journal ArticleDOI
Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind, randomised controlled trial
Ankur Gupta-Wright,Ankur Gupta-Wright,Elizabeth L. Corbett,Elizabeth L. Corbett,Joep J. van Oosterhout,Joep J. van Oosterhout,Douglas Wilson,Daniel Grint,Melanie Alufandika-Moyo,Jurgens A Peters,Lingstone Chiume,Clare Flach,Clare Flach,Stephen D. Lawn,Katherine Fielding,Katherine Fielding +15 more
TL;DR: Urine-based tuberculosis screening did not reduce overall mortality in all HIV-positive inpatients, but might benefit some high-risk subgroups, and implementation could contribute towards global targets to reduce tuberculosis mortality.
Journal ArticleDOI
Cost-effectiveness of urine-based tuberculosis screening in hospitalised patients with HIV in Africa: a microsimulation modelling study
Krishna P. Reddy,Ankur Gupta-Wright,Ankur Gupta-Wright,Katherine Fielding,Katherine Fielding,Sydney Costantini,Amy Zheng,Elizabeth L. Corbett,Elizabeth L. Corbett,Liyang Yu,Joep J. van Oosterhout,Joep J. van Oosterhout,Stephen C Resch,Douglas Wilson,C. Robert Horsburgh,Robin Wood,Melanie Alufandika-Moyo,Jurgens A Peters,Kenneth A. Freedberg,Stephen D. Lawn,Stephen D. Lawn,Rochelle P. Walensky +21 more
TL;DR: Urine TB-LAM is especially attractive because of high incremental diagnostic yield and low additional cost compared with sputum Xpert, making a compelling case for expanding its use to all hospitalised patients with HIV in areas with high HIV burden and endemic tuberculosis.
Journal ArticleDOI
Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study.
Ankur Gupta-Wright,Ankur Gupta-Wright,Elizabeth L. Corbett,Elizabeth L. Corbett,Douglas Wilson,Joep J. van Oosterhout,Joep J. van Oosterhout,Keertan Dheda,Helena Huerga,Jonny Peter,Maryline Bonnet,Melanie Alufandika-Moyo,Melanie Alufandika-Moyo,Daniel Grint,Stephen D. Lawn,Katherine Fielding,Katherine Fielding +16 more
TL;DR: A simple clinical risk score to predict mortality in high-burden, low-resource settings is capable of identifying patients who could benefit from enhanced clinical care, follow-up, and/or adjunctive interventions, although further prospective validation studies are necessary.
Journal ArticleDOI
Rapid urine-based screening for tuberculosis to reduce AIDS-related mortality in hospitalized patients in Africa (the STAMP trial): study protocol for a randomised controlled trial
Ankur Gupta-Wright,Ankur Gupta-Wright,Katherine Fielding,Katherine Fielding,Joep J. van Oosterhout,Joep J. van Oosterhout,Douglas Wilson,Elizabeth L. Corbett,Elizabeth L. Corbett,Clare Flach,Krishna P. Reddy,Rochelle P. Walensky,Jurgens A Peters,Melanie Alufandika-Moyo,Stephen D. Lawn,Stephen D. Lawn +15 more
TL;DR: The STAMP trial aims to test the hypothesis that the implementation a urine-based screening strategy for TB can reduce all cause-mortality among HIV-positive patients admitted to hospital when compared to current, sputum-based Screening for TB.
Journal ArticleDOI
Tuberculosis in Hospitalized Patients With Human Immunodeficiency Virus: Clinical Characteristics, Mortality, and Implications From the Rapid Urine-based Screening for Tuberculosis to Reduce AIDS Related Mortality in Hospitalized Patients in Africa.
Ankur Gupta-Wright,Ankur Gupta-Wright,Katherine Fielding,Katherine Fielding,Douglas Wilson,Joep J. van Oosterhout,Joep J. van Oosterhout,Daniel Grint,Henry C. Mwandumba,Henry C. Mwandumba,Melanie Alufandika-Moyo,Jurgens A Peters,Lingstone Chiume,Stephen D. Lawn,Elizabeth L. Corbett,Elizabeth L. Corbett +15 more
TL;DR: Mortality following prompt inpatient diagnosis of HIV-associated TB remained unacceptably high, even in South Africa, and intensified management strategies are urgently needed.