M
Myungjin Kim
Researcher at University of Southern California
Publications - 9
Citations - 3271
Myungjin Kim is an academic researcher from University of Southern California. The author has contributed to research in topics: DNA methylation & CpG site. The author has an hindex of 8, co-authored 9 publications receiving 3106 citations.
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Journal ArticleDOI
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
Daniel J. Weisenberger,Kimberly D. Siegmund,Mihaela Campan,Joanne P. Young,Tiffany I. Long,Mark A Faasse,Gyeong Hoon Kang,Martin Widschwendter,Deborah Weener,Daniel D. Buchanan,Hoey Koh,Lisa A. Simms,Melissa A. Barker,Barbara A. Leggett,Joan Levine,Myungjin Kim,Amy J. French,Stephen N. Thibodeau,Jeremy R. Jass,Robert W. Haile,Peter W. Laird +20 more
TL;DR: A systematic, stepwise screen of 195 CpG island methylation markers using MethyLight technology found that CIMP-positive (CIMP+) tumors convincingly represent a distinct subset, encompassing almost all cases of tumors with BRAFmutation (odds ratio = 203).
Journal ArticleDOI
Analysis of repetitive element DNA methylation by MethyLight
Daniel J. Weisenberger,Mihaela Campan,Tiffany I. Long,Myungjin Kim,Christian B. Woods,Emerich S. Fiala,Melanie Ehrlich,Peter W. Laird +7 more
TL;DR: This work reports the development of quantitative MethyLight assays to determine the levels of methylated and unmethylated repeats, namely, Alu and LINE-1 sequences and the centromeric satellite alpha (Satα) and juxtacentromeric satellites 2 (Sat2) DNA sequences.
Journal ArticleDOI
DNA methylation as a biomarker for cardiovascular disease risk.
TL;DR: The findings indicate that elevated, not decreased, PBL DNA methylation is positively associated with prevalence of CVD/predisposing conditions and obesity in Singapore Chinese.
Journal ArticleDOI
Analysis of the Association between CIMP and BRAFV600E in Colorectal Cancer by DNA Methylation Profiling
Toshinori Hinoue,Daniel J. Weisenberger,Fei Pan,Mihaela Campan,Myungjin Kim,Joanne P. Young,Joanne P. Young,Vicki L. J. Whitehall,Barbara A. Leggett,Peter W. Laird +9 more
TL;DR: CIMP-specific inactivation of BRAFV600E-induced senescence and apoptosis pathways by IGFBP7 DNA hypermethylation might create a favorable context for the acquisition of BRAfV 600E in CIMP+ colorectal cancer.
Journal ArticleDOI
DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status
Brian L. Pike,Timothy C. Greiner,Xiaoming Wang,Dennis D. Weisenburger,Ya-Hsuan Hsu,Gabriel Renaud,Tyra G. Wolfsberg,Myungjin Kim,Daniel J. Weisenberger,Kimberly D. Siegmund,Wei Ye,Susan Groshen,Ruty Mehrian-Shai,Jan Delabie,Wing C. Chan,Peter W. Laird,Peter W. Laird,Joseph G. Hacia +17 more
TL;DR: The proportional reductions in BNIP3, MGMT, RBP1, GATA4, IGSF4, CRABP1 and FLJ21062 expression with increasing methylation suggest that epigenetic processes strongly influence these genes.