T
Tiffany I. Long
Researcher at University of Southern California
Publications - 31
Citations - 6673
Tiffany I. Long is an academic researcher from University of Southern California. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 24, co-authored 31 publications receiving 6361 citations. Previous affiliations of Tiffany I. Long include Good Samaritan Hospital.
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Journal ArticleDOI
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
Daniel J. Weisenberger,Kimberly D. Siegmund,Mihaela Campan,Joanne P. Young,Tiffany I. Long,Mark A Faasse,Gyeong Hoon Kang,Martin Widschwendter,Deborah Weener,Daniel D. Buchanan,Hoey Koh,Lisa A. Simms,Melissa A. Barker,Barbara A. Leggett,Joan Levine,Myungjin Kim,Amy J. French,Stephen N. Thibodeau,Jeremy R. Jass,Robert W. Haile,Peter W. Laird +20 more
TL;DR: A systematic, stepwise screen of 195 CpG island methylation markers using MethyLight technology found that CIMP-positive (CIMP+) tumors convincingly represent a distinct subset, encompassing almost all cases of tumors with BRAFmutation (odds ratio = 203).
Journal ArticleDOI
Analysis of repetitive element DNA methylation by MethyLight
Daniel J. Weisenberger,Mihaela Campan,Tiffany I. Long,Myungjin Kim,Christian B. Woods,Emerich S. Fiala,Melanie Ehrlich,Peter W. Laird +7 more
TL;DR: This work reports the development of quantitative MethyLight assays to determine the levels of methylated and unmethylated repeats, namely, Alu and LINE-1 sequences and the centromeric satellite alpha (Satα) and juxtacentromeric satellites 2 (Sat2) DNA sequences.
Journal Article
Epigenetic patterns in the progression of esophageal adenocarcinoma.
Cindy A. Eads,Reginald V. Lord,Kumari Wickramasinghe,Tiffany I. Long,Soudamini K. Kurumboor,Leslie Bernstein,Jeffrey H. Peters,Steven R. DeMeester,Tom R. DeMeester,Kristin A. Skinner,Peter W. Laird +10 more
TL;DR: The fact that the samples from these two groups of patients were histologically indistinguishable, yet molecularly distinct, suggests that the occurrence of such hypermethylation may provide a clinical tool to identify patients with premalignant Barrett's who are at risk for further progression.
Journal ArticleDOI
Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium.
Jochen Müller-Ehmsen,Peter Whittaker,Robert A. Kloner,Joan Dow,Tsuyoshi Sakoda,Tiffany I. Long,Peter W. Laird,Larry Kedes +7 more
TL;DR: A quantitative survival profile for neonatal cardiomyocytes transplanted into normal adult myocardium is established, revealing that transplanted cells became more elongated over time, developed cross-striations, and that their nuclei increased in size.
Journal ArticleDOI
DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons
Kimberly D. Siegmund,Caroline M. Connor,Mihaela Campan,Tiffany I. Long,Daniel J. Weisenberger,Detlev Biniszkiewicz,Rudolf Jaenisch,Peter W. Laird,Schahram Akbarian +8 more
TL;DR: DNA methylation is dynamically regulated in the human cerebral cortex throughout the lifespan, involves differentiated neurons, and affects a substantial portion of genes predominantly by an age-related increase.