M
Melanie Fischer
Researcher at MorphoSys
Publications - 3
Citations - 1122
Melanie Fischer is an academic researcher from MorphoSys. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 1096 citations.
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Journal ArticleDOI
Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.
Achim Knappik,Liming Ge,Annemarie Honegger,Peter Pack,Melanie Fischer,Günter Wellnhofer,Adolf Hoess,Joachim Wölle,Andreas Plückthun,Bernhard Virnekäs +9 more
TL;DR: The small number of 49 master genes will allow future improvements to be incorporated quickly, and the separation of the frameworks may help in analyzing why nature has evolved these distinct subfamilies of antibody germline genes.
Journal ArticleDOI
High-Throughput and Format-Agnostic Mispairing Assay for Multispecific Antibodies Using Intact Mass Spectrometry.
Katja Kroll,Marion Schneider,Nadja Spindler,Dilyana Dimova,Arnd Brandenburg,Reto Ossola,Norbert Furtmann,Joerg Birkenfeld,Christian Beil,Dietmar Hoffmann,Thorsten Schmidt,Melanie Fischer,Soraya Hölper +12 more
TL;DR: In this article , the authors developed a high-throughput-capable mispairing workflow based on intact mass spectrometry with automated data analysis, peak detection, and relative quantification using Genedata Expressionist.