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Norbert Furtmann
Researcher at University of Bonn
Publications - 32
Citations - 630
Norbert Furtmann is an academic researcher from University of Bonn. The author has contributed to research in topics: Docking (molecular) & Butyrylcholinesterase. The author has an hindex of 15, co-authored 30 publications receiving 548 citations. Previous affiliations of Norbert Furtmann include Center for Information Technology.
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Structural Optimization of Azadipeptide Nitriles Strongly Increases Association Rates and Allows the Development of Selective Cathepsin Inhibitors
TL;DR: Using the example of cathepsin K, the design of highly potent and selective azadipeptide nitrile inhibitors is demonstrated using a combination of optimized P2 and P3 substituents with a methylation of the P3-P2 amide linker.
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Current compound coverage of the kinome.
TL;DR: Publicly available kinase inhibitors have been analyzed in detail and it is found that about half of the human kinome is currently covered with active small molecules.
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Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors
Abdul Hameed,Khalid Mohammed Khan,Syeda Tazeen Zehra,Ramasa Ahmed,Zahid Shafiq,Syeda Mahwish Bakht,Muhammad Yaqub,Mazhar Hussain,Antonio de la Vega de León,Norbert Furtmann,Jürgen Bajorath,Hazoor Ahmad Shad,Muhammad Tahir,Jamshed Iqbal +13 more
TL;DR: In this article, a series of 19 benzofurane linked N-phenyl semithiocarbazones (3a-3s) were synthesized for enzyme inhibitor activity against Jack bean urease.
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Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.
Imtiaz Khan,Aliya Ibrar,Sumera Zaib,Sarfraz Ahmad,Norbert Furtmann,Shahid Hameed,Jim Simpson,Jürgen Bajorath,Jamshed Iqbal +8 more
TL;DR: In an effort to identify novel cholinesterase candidates for the treatment of Alzheimer's disease (AD), a diverse array of potentially bioactive compounds including triazolothiadiazoles and triazoliadiazines was obtained in good yields through the cyclocondensation reaction of 4-amino-5-(pyridin- 3-yl)-4H-1,2,4-triazole-3-thiol.
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Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors
Aliya Ibrar,Yildiz Tehseen,Imtiaz Khan,Abdul Hameed,Aamer Saeed,Norbert Furtmann,Jürgen Bajorath,Jamshed Iqbal +7 more
TL;DR: Docking studies performed using X-ray structures of ALR1 and ALR2 with the given synthesized inhibitors showed that coumarinyl thiazole series lacks the carboxylate function that could interact with the anionic binding site being a common AlR1/ALR2 inhibitors trait.