M
Melanie J. Hamblen-Coyle
Researcher at Brandeis University
Publications - 9
Citations - 1395
Melanie J. Hamblen-Coyle is an academic researcher from Brandeis University. The author has contributed to research in topics: Period (gene) & CLOCK. The author has an hindex of 9, co-authored 9 publications receiving 1361 citations.
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Journal ArticleDOI
Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms.
TL;DR: Using internally marked mosaics, it is found that the pacemaker is located in brain but is not exclusive to the eyes, the ocelli, or the optic lobes, which is consistent with previous reports obtained in this and other insects of this class.
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Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both.
TL;DR: The data, in contrast to some previous conclusions, strongly suggest that period0 (per0 ) adults are, in LD conditions, merely being "forced" into exhibiting periodic behavior.
Journal ArticleDOI
A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system.
B. Frisch,Paul E. Hardin,Paul E. Hardin,Melanie J. Hamblen-Coyle,Michael Rosbash,Michael Rosbash,Jeffrey C. Hall +6 more
TL;DR: Cycling of PER in brain cells of flies carrying the same 7.2 kb piece of per DNA under the control of a heat shock promoter corroborated the hypothesis that per's molecular cyclings and behavioral rhythmicity are causally related.
Journal ArticleDOI
Behavior of period-altered circadian rhythm mutants of Drosophila in light: Dark cycles (Diptera: Drosophilidae)
Melanie J. Hamblen-Coyle,David A. Wheeler,Joan E. Rutila,Joan E. Rutila,Michael Rosbash,Michael Rosbash,Jeffrey C. Hall +6 more
TL;DR: The phases of the evening peaks of activity under LD conditions were correspondingly earlier thannormal for the short-period mutants and later than normal for those with long circadian cycle durations, and the morning peaks moved minimally under the influence of a given pervariant.
Journal ArticleDOI
Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling.
Ralf Stanewsky,B. Frisch,Christian Brandes,Melanie J. Hamblen-Coyle,Michael Rosbash,Jeffrey C. Hall +5 more
TL;DR: The XLG construct restored weak behavioral rhythmicity to per01 flies, indicating that the C-terminal third of PER (missing in BG) is necessary to fulfill the biological function of this clock protein.