M
Melanie Van Stry
Researcher at Lane College
Publications - 19
Citations - 261
Melanie Van Stry is an academic researcher from Lane College. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 8, co-authored 11 publications receiving 229 citations. Previous affiliations of Melanie Van Stry include St. Jude Children's Research Hospital & Boston University.
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Journal ArticleDOI
Mina, an Il4 repressor, controls T helper type 2 bias.
Mariko Okamoto,Melanie Van Stry,Linda Chung,Madoka Koyanagi,Xizhang Sun,Yoshie Suzuki,Osamu Ohara,Hiroshi Kitamura,Atsushi Hijikata,Masato Kubo,Mark Bix +10 more
TL;DR: Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4+ T cells led to Il4 derepression, which provides mechanistic insight into an Il4-regulatory pathway that controls helper T cell differentiation and genetic variation in TH2 bias.
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Enhanced Susceptibility of Ago1/3 Double-Null Mice to Influenza A Virus Infection
Melanie Van Stry,Thomas H. Oguin,Sihem Cheloufi,Peter Vogel,Makiko Watanabe,Meenu R. Pillai,Pradyot Dash,Paul G. Thomas,Gregory J. Hannon,Gregory J. Hannon,Mark Bix +10 more
TL;DR: The results support the notion that the enhanced flu susceptibility of double-knockout mice arises from an intrinsic impairment in the ability of lung cells to tolerate flu-elicited inflammation.
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Distinct effectors of platelet-derived growth factor receptor-α signaling are required for cell survival during embryogenesis
TL;DR: Findings show that PDGFRalpha signaling through PLCgamma and phosphatidylinositol 3-kinase has a protective role in preventing apoptosis in early development, and it is demonstrated that small molecule inducers of dimerization provide a powerful system to manipulate receptor function in developing embryos.
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Apoptosis regulates notochord development in Xenopus
TL;DR: It is shown that early notochord development in Xenopus embryos is regulated by apoptosis, and data indicate that apoptosis is required for normal notochords development during the formation of the anterior-posterior axis.
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The mitochondrial-apoptotic pathway is triggered in Xenopus mesoderm cells deprived of PDGF receptor signaling during gastrulation.
TL;DR: It is proposed that PDGFR signaling is necessary for survival of prospective head mesoderm cells, and also plays an essential role in the control of their cell movement during gastrulation.