M
Masato Kubo
Researcher at Tokyo University of Science
Publications - 186
Citations - 16185
Masato Kubo is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 62, co-authored 172 publications receiving 14363 citations. Previous affiliations of Masato Kubo include University of the Sciences & University of Tokyo.
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Journal ArticleDOI
SOCS proteins, cytokine signalling and immune regulation.
TL;DR: This review brings together data from recent studies on SOCS proteins and their role in immunity, and proposes a cohesive model of how cytokine signalling regulates immune-cell function.
Journal ArticleDOI
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein.
Li-Fan Lu,To-Ha Thai,Dinis Pedro Calado,Ashutosh Chaudhry,Masato Kubo,Kentaro Tanaka,Gabriel B. Loeb,Hana Lee,Akihiko Yoshimura,Akihiko Yoshimura,Klaus Rajewsky,Alexander Y. Rudensky +11 more
TL;DR: It is found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions and provides experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes.
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SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
Ichiko Kinjyo,Toshikatsu Hanada,Kyoko Inagaki-Ohara,Hiroyuki Mori,Daisuke Aki,Masanobu Ohishi,Hiroki Yoshida,Masato Kubo,Akihiko Yoshimura +8 more
TL;DR: It is shown that the suppressor of cytokine-signaling-1 (SOCS1/JAB) is rapidly induced by LPS and negatively regulates LPS signaling, which directly suppresses TLR4 signaling and modulates innate immunity.
Journal ArticleDOI
Suppressors of cytokine signaling and immunity
TL;DR: The function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCs, is reviewed.
Journal ArticleDOI
NetPath: a public resource of curated signal transduction pathways
Kumaran Kandasamy,Subburaman Mohan,Rajesh Raju,Shivakumar Keerthikumar,Ghantasala S. Sameer Kumar,Abhilash K. Venugopal,Deepthi Telikicherla,Daniel J. Navarro,Suresh Mathivanan,Christian Pecquet,Sashi Kanth Gollapudi,Sudhir Gopal Tattikota,Shyam Mohan,Hariprasad Padhukasahasram,Yashwanth Subbannayya,Renu Goel,Harrys K.C. Jacob,Jun Zhong,Raja Sekhar,Vishalakshi Nanjappa,Lavanya Balakrishnan,Roopashree Subbaiah,Y. L. Ramachandra,B. Abdul Rahiman,T. S. Keshava Prasad,Jian Xin Lin,Jon C. D. Houtman,Stephen Desiderio,Jean-Christophe Renauld,Stefan N. Constantinescu,Osamu Ohara,Toshio Hirano,Masato Kubo,S. Singh,Purvesh Khatri,Sorin Draghici,Gary D. Bader,Gary D. Bader,Chris Sander,Warren J. Leonard,Akhilesh Pandey +40 more
TL;DR: NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles.