M
Melinda L. Irwin
Researcher at Yale University
Publications - 205
Citations - 23189
Melinda L. Irwin is an academic researcher from Yale University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 60, co-authored 179 publications receiving 20816 citations. Previous affiliations of Melinda L. Irwin include Fred Hutchinson Cancer Research Center & Yale Cancer Center.
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Journal ArticleDOI
Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial.
Kristin L. Campbell,Anne McTiernan,Anne McTiernan,Shuying S. Li,Bess Sorensen,Yutaka Yasui,Johanna W. Lampe,Irena B. King,Cornelia M. Ulrich,Rebecca E. Rudolph,Melinda L. Irwin,Christina M. Surawicz,Kamran Ayub,John D. Potter,Paul D. Lampe +14 more
TL;DR: A 12-month exercise intervention resulted in greater expression of proteins that promote apoptosis at the bottom of colon crypts in men and decreased expression of protein that promote euthanasia at the middle and top of colon Crypts in women.
Journal ArticleDOI
Mammographic Density Change with 1 Year of Aerobic Exercise among Postmenopausal Women: A Randomized Controlled Trial
Christy G. Woolcott,Kerry S. Courneya,Norman F. Boyd,Martin J. Yaffe,Tim Terry,Anne McTiernan,Rollin Brant,Rachel Ballard-Barbash,Melinda L. Irwin,Charlotte Jones,Sony Brar,Kristin L. Campbell,Margaret L. McNeely,Kristina H. Karvinen,Christine M. Friedenreich +14 more
TL;DR: The data from this study suggest that the protective effect of exercise on breast cancer risk may operate through a mechanism other than mammographic density, which may require more exercise or a study population with higher baseline levels of sex hormones or a wider range of mammographicdensity.
Journal ArticleDOI
Sedentary Behavior, Health-Related Quality of Life, and Fatigue Among Breast Cancer Survivors
Stephanie M. George,Catherine M. Alfano,Ashley Wilder Smith,Melinda L. Irwin,Anne McTiernan,Leslie Bernstein,Kathy B. Baumgartner,Rachel Ballard-Barbash +7 more
TL;DR: Self-reported sedentary time was not associated with HRQOL or fatigue, 3.5 years postdiagnosis in this breast cancer survivor cohort, and the role of sedentary behavior in that relationship was not known.
Journal ArticleDOI
Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women's Activity and Lifestyle Study in Connecticut (WALC).
Yang Zhou,Yang Zhou,Brenda Cartmel,Brenda Cartmel,Linda Gottlieb,Elizabeth Ercolano,Fangyong Li,Maura Harrigan,Ruth McCorkle,Ruth McCorkle,Jennifer A. Ligibel,Vivian E. von Gruenigen,Radhika Gogoi,Peter E. Schwartz,Harvey A. Risch,Harvey A. Risch,Melinda L. Irwin,Melinda L. Irwin +17 more
TL;DR: A six-month home-based, telephone-delivered exercise intervention of primarily brisk walking to be associated with improved physical HRQOL in women with ovarian cancer and oncologists and primary care providers should recommend and refer women diagnosed with ovarian cancer to clinic- or community-based exercise programs.
Journal ArticleDOI
Effect of Exercise on Metabolic Syndrome Variables in Breast Cancer Survivors
TL;DR: Adhering to the exercise intervention resulted in a significant decrease in metabolic syndrome z-score from baseline to 6 months, which indicates increasing exercise adherence is a necessary target for further research in obese breast cancer survivors.