M
Melinda R. Baerwald
Researcher at California Department of Water Resources
Publications - 49
Citations - 1337
Melinda R. Baerwald is an academic researcher from California Department of Water Resources. The author has contributed to research in topics: Population & Smelt. The author has an hindex of 17, co-authored 41 publications receiving 1231 citations. Previous affiliations of Melinda R. Baerwald include University of California, Berkeley & University of California, San Francisco.
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Journal ArticleDOI
Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation
Li Wha Wu,Lindsey D. Mayo,James D. Dunbar,Kelly M. Kessler,Melinda R. Baerwald,Eric A. Jaffe,Dongfang Wang,Robert S. Warren,David B. Donner +8 more
TL;DR: Two-hybrid cloning and immunoprecipitation from human umbilical vein endothelial cells (HUVEC) showed that KDR binds to and promotes the tyrosine phosphorylation of phospholipase Cγ (PLCγ), indicating that K DR is uniquely important to PLCγ activation in HUVEC.
Journal ArticleDOI
Tumor Necrosis Factor Employs a Protein-tyrosine Phosphatase to Inhibit Activation of KDR and Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation
Dan Qun Guo,Li Wha Wu,James D. Dunbar,Osman N. Ozes,Lindsey D. Mayo,Kelly M. Kessler,Jason A. Gustin,Melinda R. Baerwald,Eric A. Jaffe,Robert S. Warren,David B. Donner +10 more
TL;DR: Heterologous receptor inactivation mediated by a protein-tyrosine phosphatase provides insight into how TNF may inhibit endothelial cell proliferative responses and modulate angiogenesis in pathological settings.
Journal ArticleDOI
Migration-related phenotypic divergence is associated with epigenetic modifications in rainbow trout
Melinda R. Baerwald,Mariah H. Meek,Molly R. Stephens,Raman P. Nagarajan,Alisha Goodbla,Katharine M. Tomalty,Gary H. Thorgaard,Bernie May,Krista M. Nichols +8 more
TL;DR: This study provides the first evidence of a relationship between epigenetic variation and life history divergence associated with migration‐related traits in any species.
Journal ArticleDOI
A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss).
TL;DR: This work confirms that a single QTL region on chromosome Omy9 is capable of explaining a large percentage of the phenotypic variance contributing to whirling disease resistance and moves the field closer to a mechanistic understanding of resistance to this important disease of salmonid fish.
Journal ArticleDOI
Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells
Jason A. Gustin,Roxana Pincheira,Lindsey D. Mayo,Osman N. Ozes,Kelly M. Kessler,Melinda R. Baerwald,Chandrashekhar K. Korgaonkar,David B. Donner +7 more
TL;DR: Observations show that CREB is activated by TNF/TNFR1 signaling through a p38MAPK/MSK1 signaling pathway, and that downstream of p38 MAPK, MSK1 is activatedby TNF to promote CREB activation.