M
Melis Kartal Yandim
Researcher at İzmir Institute of Technology
Publications - 11
Citations - 537
Melis Kartal Yandim is an academic researcher from İzmir Institute of Technology. The author has contributed to research in topics: Apoptosis & Jurkat cells. The author has an hindex of 6, co-authored 11 publications receiving 414 citations. Previous affiliations of Melis Kartal Yandim include İzmir University of Economics.
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Journal ArticleDOI
Major apoptotic mechanisms and genes involved in apoptosis.
TL;DR: This review has focused on the gene families playing critical roles, activation/inactivation mechanisms, upstream/downstream effectors, and signaling pathways in apoptosis on the basis of cancer studies and novel apoptotic players such as miRNAs and sphingolipid family members in various kind of cancer are discussed.
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Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer
TL;DR: In various types of cancers, overexpression of GCS has been observed which renders GCS a good target for the treatment of cancer and the mechanism underlying the drug resistance which develops with increased glucosylceramide expression is associated with P-glycoprotein.
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New indication for therapeutic potential of an old well-known drug (propranolol) for multiple myeloma
Ilknur Kozanoglu,Melis Kartal Yandim,Zeynep Birsu Cincin,Hakan Ozdogu,Bedia Cakmakoglu,Yusuf Baran +5 more
TL;DR: It is revealed that propranolol has antiproliferative and apoptotic effects on multiple myeloma cells and being supported with in vivo analyses, proPRanolol can be a good and economical way to treat multiple myELoma patients.
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Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted “hsa-miR-2278” as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A
Burçin Tezcanlı Kaymaz,Nur Selvi Günel,Metin Ceyhan,Vildan Bozok Çetintaş,Buket Özel,Melis Kartal Yandim,Sezgi Kipcak,Çağdaş Aktan,Aysun Adan Gökbulut,Yusuf Baran,Buket Kosova Can +10 more
TL;DR: This study provides new insights in discovering the mechanism of imatinib resistance due to upregulating the tumor-suppressor hsa-miR-2278 which stands for a functional therapeutic approach, inhibited leukemic cell proliferation, induced apoptosis, and regain of chemotherapeutic drug response in CML therapy.
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Effects of cell-mediated osteoprotegerin gene transfer and mesenchymal stem cell applications on orthodontically induced root resorption of rat teeth
Nisa Gül Amuk,Gökmen Kurt,Yusuf Baran,Yusuf Baran,Volkan Seyrantepe,Melis Kartal Yandim,Melis Kartal Yandim,Aysun Adan,Aysun Adan,Secil Akyildiz Demir,Yağmur Kiraz,Yağmur Kiraz,Mehmet Fatih Sönmez +12 more
TL;DR: MSCs and GT showed marked inhibition and/or repair effects on OIIRR during orthodontic treatment on rats.