M
Melissa A. Miller
Researcher at University of Iowa
Publications - 5
Citations - 683
Melissa A. Miller is an academic researcher from University of Iowa. The author has contributed to research in topics: Leishmania chagasi & Leishmania. The author has an hindex of 5, co-authored 5 publications receiving 649 citations. Previous affiliations of Melissa A. Miller include Veterans Health Administration.
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Journal ArticleDOI
Oxidative Responses of Human and Murine Macrophages During Phagocytosis of Leishmania chagasi
Kira R. Gantt,Todd L. Goldman,Michael L. McCormick,Michael L. McCormick,Melissa A. Miller,Selma M. B. Jeronimo,Eliana T. Nascimento,Bradley E. Britigan,Bradley E. Britigan,Mary E. Wilson +9 more
TL;DR: It is demonstrated that murine and human macrophages produce O2− during phagocytosis of opsonized promastigotes and NO· each contribute to intracellular killing of L. chagasi in human and murine macrophage.
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Activation of TGF-β by Leishmania chagasi: Importance for Parasite Survival in Macrophages
Kira R. Gantt,Stacey Schultz-Cherry,Nilda E. Rodríguez,Selma M. B. Jeronimo,Eliana T. Nascimento,Todd L. Goldman,Thomas J. Recker,Melissa A. Miller,Mary E. Wilson +8 more
TL;DR: It is hypothesize that the combined effect of abundant TGF-β stores at extracellular sites during infection, and the ability of the parasite to activate T GF-β in its local environment, leads to high levels of active TGF -β in the vicinity of the infected macrophage.
Journal ArticleDOI
Inducible Resistance to Oxidant Stress in the Protozoan Leishmania chagasi
Melissa A. Miller,Stephen E. McGowan,Kira R. Gantt,Matthew M. Champion,Sherry L. Novick,Kurt A. Andersen,Cyrus J. Bacchi,Nigel Yarlett,Bradley E. Britigan,Mary E. Wilson +9 more
TL;DR: It is concluded that leishmania have redundant mechanisms for resisting toxic oxidants, some are induced during developmental change and others are induced in response to environmental stress.
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Leishmania chagasi: uptake of iron bound to lactoferrin or transferrin requires an iron reductase
TL;DR: Data support a model in which a parasite-associated or secreted reductase reduces ferric to ferrous iron, decreasing its affinity for the extracellular chelate and allowing it to be readily internalized by the parasite.
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Regulation of GP63 mRNA stability in promastigotes of virulent and attenuated Leishmania chagasi.
TL;DR: Results indicate that the t(1/2) of mspL RNA is maintained by at least two distinct mechanisms - one activated during growth to stationary phase and the other dependent on a labile negative regulatory protein factor(s).