M
Melissa G. Mendez
Researcher at University of Pennsylvania
Publications - 14
Citations - 3271
Melissa G. Mendez is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Vimentin & Intermediate filament. The author has an hindex of 12, co-authored 14 publications receiving 2909 citations. Previous affiliations of Melissa G. Mendez include Northwestern University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.
Robert D. Goldman,Dale K. Shumaker,Michael R. Erdos,Maria Eriksson,Anne E. Goldman,Leslie B. Gordon,Leslie B. Gordon,Yosef Gruenbaum,Satya Khuon,Melissa G. Mendez,Renee Varga,Francis S. Collins +11 more
TL;DR: It is shown by light and electron microscopy that HGPS is associated with significant changes in nuclear shape, including lobulation of the nuclear envelope, thickening of thenuclear lamina, loss of peripheral heterochromatin, and clustering of nuclear pores.
Journal ArticleDOI
Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
TL;DR: Vimentin is used widely as a marker of the epithelial to mesenchymal transitions that take place during embryogenesis and metastasis, yet the functional implications of the expression of this type III intermediate filament (IF) protein are poorly understood.
Journal ArticleDOI
Introducing intermediate filaments: from discovery to disease.
John E. Eriksson,Thomas Dechat,Boris Grin,Brian T. Helfand,Melissa G. Mendez,Hanna Mari Pallari,Hanna Mari Pallari,Robert D. Goldman +7 more
TL;DR: It took more than 100 years before it was established that the proteins that form intermediate filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in virtually all differentiated cells and present both in the cytoplasm and in the nucleus.
Journal ArticleDOI
Vimentin organization modulates the formation of lamellipodia
Brian T. Helfand,Melissa G. Mendez,S. N. Prasanna Murthy,Dale K. Shumaker,Boris Grin,Saleemulla Mahammad,Ueli Aebi,Tatjana Wedig,Yi I. Wu,Klaus M. Hahn,Masaki Inagaki,Harald Herrmann,Robert D. Goldman +12 more
TL;DR: The disassembly and withdrawal of vimentin intermediate filaments from the plasma membrane induces membrane ruffling and the formation of a lamellipodium and this formation is inhibited when VIF are present.
Journal ArticleDOI
Vimentin Enhances Cell Elastic Behavior and Protects against Compressive Stress
TL;DR: The results show that the Young's moduli of normal and vim(-/-)mEFs are substrate stiffness dependent even when the spread area is similar, and that vimentin protects against compressive stress and preserves mechanical integrity by enhancing cell elastic behavior.