D
Dale K. Shumaker
Researcher at Northwestern University
Publications - 26
Citations - 7162
Dale K. Shumaker is an academic researcher from Northwestern University. The author has contributed to research in topics: Lamin & Nuclear lamina. The author has an hindex of 25, co-authored 26 publications receiving 6504 citations. Previous affiliations of Dale K. Shumaker include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.
Robert D. Goldman,Dale K. Shumaker,Michael R. Erdos,Maria Eriksson,Anne E. Goldman,Leslie B. Gordon,Leslie B. Gordon,Yosef Gruenbaum,Satya Khuon,Melissa G. Mendez,Renee Varga,Francis S. Collins +11 more
TL;DR: It is shown by light and electron microscopy that HGPS is associated with significant changes in nuclear shape, including lobulation of the nuclear envelope, thickening of thenuclear lamina, loss of peripheral heterochromatin, and clustering of nuclear pores.
Journal ArticleDOI
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
Thomas Dechat,Katrin Pfleghaar,Kaushik Sengupta,Takeshi Shimi,Dale K. Shumaker,Liliana Solimando,Robert D. Goldman +6 more
TL;DR: An up-to-date overview of the functions of nuclear lamins is provided, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair.
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The nuclear lamina comes of age
TL;DR: These complexes provide new insights into cell architecture, as a foundation for the understanding of the molecular mechanisms that underlie the human laminopathies — clinical disorders that range from Emery–Dreifuss muscular dystrophy to the accelerated ageing seen in Hutchinson–Gilford progeria syndrome.
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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Dale K. Shumaker,Thomas Dechat,Alexander Kohlmaier,Alexander Kohlmaier,Stephen A. Adam,Matthew R. Bozovsky,Michael R. Erdos,Maria Eriksson,Anne E. Goldman,Satya Khuon,Francis S. Collins,Thomas Jenuwein,Robert D. Goldman +12 more
TL;DR: The epigenetic changes described most likely represent molecular mechanisms responsible for the rapid progression of premature aging in HGPS patients.
Journal ArticleDOI
Nuclear lamins: building blocks of nuclear architecture
Robert D. Goldman,Yosef Gruenbaum,Yosef Gruenbaum,Robert D. Moir,Dale K. Shumaker,Timothy P. Spann +5 more
TL;DR: Experimental and genetic evidence suggest that nuclear lamins are involved in a number of other functions including nuclear envelope assembly, DNA synthesis, transcription, and apoptosis, and speculate about possible mechanisms through which mutations in lamins give rise to disease.