Effects of nickel exposure on testicular function, oxidative stress, and male reproductive dysfunction in Spodoptera litura Fabricius

Trace metal contamination: Transfer and fate in food chains of terrestrial invertebrates

Reproduction and development of Spodoptera exigua from cadmium and control strains under differentiated cadmium stress.

Molecular changes in vitellogenin gene of Spodoptera exigua after long-time exposure to cadmium - Toxic side effect or microevolution?

Effects of zinc acquired through the plant-aphid-ladybug food chain on the growth, development and fertility of Harmonia axyridis.

Background
Contamination, including metals, can disturb the reproductive processes of many organisms, including both prey and predatory insects. However, there is virtually no information on the effects of high level Zinc (Zn) pollution on aphids and ladybirds. The high concentrations of Zn2+ or Zn pollution inhibit reproduction in the phytophagous aphid, Aphis medicaginis, and the predatory ladybird Harmonia axyridis could provide important information.

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Inhibitional Effects of Metal Zn2+ on the Reproduction of Aphis medicaginis and Its Predation by Harmonia axyridis

Characterization of triclosan-induced hepatotoxicity and triclocarban-triggered enterotoxicity in mice by multiple omics screening.

Study on flexible thin air electrodes and electrochemical performance of LR6 size as well as pouch Zn-air cells

Regulation of osteoblast-mediated bone formation and osteoclast-mediated bone resorption is crucial for bone health. Currently, most clinical drugs for osteoporosis treatment such as bisphosphonates are commonly used to inhibit bone resorption but unable to promote bone formation. In this study, we discovered for the first time that icariside I (GH01), a novel prenylflavonoid isolated from Epimedium, can effectively ameliorate estrogen deficiency-induced osteoporosis with enhancement of trabecular and cortical bone in an ovariectomy (OVX) mouse model. Mechanistically, our in vitro results showed that GH01 repressed osteoclast differentiation and resorption through inhibition of RANKL-induced TRAF6-MAPK-p38-NFATc1 cascade. Simultaneously, we also found that GH01 dose-dependently promoted osteoblast differentiation and formation by inhibiting adipogenesis and accelerating energy metabolism of osteoblasts. In addition, both in vitro and in vivo studies also suggested that GH01 is not only a non-toxic natural small molecule but also beneficial for restoration of liver injury in OVX mice. These results demonstrated that GH01 has great potential for osteoporosis treatment by simultaneous regulation of osteoblast and osteoclast differentiation.

A Novel Prenylflavonoid Icariside I Ameliorates Estrogen Deficiency-Induced Osteoporosis via Simultaneous Regulation of Osteoblast and Osteoclast Differentiation.

INTRODUCTION Electronic cigarettes (e-cigarettes) have recently become popular as an alternative to conventional cigarettes. The aim of this study is to investigate the effects of e-cigarette refill liquid (e-liquid) on follicular development and estrogen secretion in rats and whether it is related to the Hippo signaling pathway, a pathway that can regulate follicle growth. METHODS Ovaries from 21- and 35-day-old rats were divided into three groups: control (no intervention), 0.05 mg, and 0.5 mg (e-liquids containing 0.5 mg and 5 mg of nicotine/kg). The rates were cultured for three hours in vitro. At the end of culture, HE staining was performed to observe the follicle morphology and calculate the percentage of normal follicles, and the expression of Yes-associated protein (YAP, target factors of the Hippo signaling pathway) and CYP19 (aromatase, a key enzyme in estrogen synthesis) were observed by immunohistochemistry. Western blotting was performed to detect the expression levels of CYP19, YAP, phosphorylated YAP (PYAP), large tumor suppressor 2 (LATS2, factors upstream of YAP in the Hippo signaling pathway), and phosphorylated LATS2 (PLATS2). Estrogen concentrations were determined using ELISA. RESULTS HE staining showed that the percentage of normal follicles decreased, and immunohistochemistry showed that the expression of CYP19 and YAP significantly decreased after e-liquid intervention. ELISA showed that the estrogen concentration in the ovaries decreased after e-liquid intervention. Western blot results indicated that CYP19, LATS2, and YAP expression, decreased after e-liquid intervention, but PLATS2 and PYAP expression increased. CONCLUSIONS We found that the e-liquids may impair the development of rat ovarian follicles and reduce estrogen secretion through Hippo signaling pathway.

Mengjing Wu

Papers

Inhibitional Effects of Metal Zn2+ on the Reproduction of Aphis medicaginis and Its Predation by Harmonia axyridis

Characterization of triclosan-induced hepatotoxicity and triclocarban-triggered enterotoxicity in mice by multiple omics screening.

Study on flexible thin air electrodes and electrochemical performance of LR6 size as well as pouch Zn-air cells

A Novel Prenylflavonoid Icariside I Ameliorates Estrogen Deficiency-Induced Osteoporosis via Simultaneous Regulation of Osteoblast and Osteoclast Differentiation.

Effect of e-cigarette refill liquid on follicular development and estrogen secretion in rats