M
Merridee A. Wouters
Researcher at Deakin University
Publications - 47
Citations - 2733
Merridee A. Wouters is an academic researcher from Deakin University. The author has contributed to research in topics: Protein structure & Genome-wide association study. The author has an hindex of 27, co-authored 47 publications receiving 2568 citations. Previous affiliations of Merridee A. Wouters include Victor Chang Cardiac Research Institute & University of New South Wales.
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Potential role of glutathione in evolution of thiol-based redox signaling sites in proteins.
Kaavya A Mohanasundaram,Naomi L. Haworth,Mani P Grover,Tamsyn M. Crowley,Andrzej Goscinski,Merridee A. Wouters +5 more
TL;DR: A redox-active disulfide may be introduced into a protein structure by stepwise mutation of two residues in the native sequence to Cys, which is likely to be the cysteine of the CSD which undergoes nucleophilic attack by thioredoxin.
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An analysis of side chain interactions and pair correlations within antiparallel β‐sheets: The differences between backbone hydrogen‐bonded and non‐hydrogen‐bonded residue pairs
TL;DR: There is a correlation between the directionality in the packing interactions of non‐H‐bonded β‐ and γ‐ Branched residue pairs, the handedness of the observed enantiomers of chiral β‐branched side chains, and the handediness of the twist of β‐sheet.
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Mutation of the LUNATIC FRINGE Gene in Humans Causes Spondylocostal Dysostosis with a Severe Vertebral Phenotype
Duncan B. Sparrow,Gavin Chapman,Merridee A. Wouters,Neil V. Whittock,Sian Ellard,Diane Fatkin,Peter D. Turnpenny,Kenro Kusumi,David Sillence,Sally L. Dunwoodie +9 more
TL;DR: This work has used a candidate-gene approach to identify a mutation in a third Notch pathway gene, LUNATIC FRINGE (LFNG), in a family with autosomal recessive SCD, and reinforces the hypothesis that proper regulation of the Notch signaling pathway is an absolute requirement for the correct patterning of the axial skeleton.
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Disulfides as Redox Switches: From Molecular Mechanisms to Functional Significance
TL;DR: The role of redox-active disulfides as switches in proteins is discussed, including the helical CXXC motif, often associated with thioredoxin-fold proteins; and forbiddendisulfides, a group of metastable disulfide that disobey elucidated rules of protein stereochemistry.
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Analysis of protein sequence and interaction data for candidate disease gene prediction
Richard A. George,Jason Y. Liu,Lina L. Feng,Robert J. Bryson-Richardson,Diane Fatkin,Merridee A. Wouters +5 more
TL;DR: Two methods to prioritize candidates for further experimental study are presented: Common Pathway Scanning (CPS) and Common Module Profiling (CMP), which prioritizes good candidates and will accelerate the disease gene discovery process.