Miao-Hsia Lin

TL;DR: A deep comprehensive proteogenomic study on a prospectively collected cohort in Taiwan, representing early stage, predominantly female, non-smoking lung adenocarcinoma, revealed the cellular remodeling underpinning clinical trajectories and nominated candidate biomarkers for patient stratification and therapeutic intervention.

TL;DR: An extensive E. coli phosphoproteome data set is generated, in which a remarkably high percentage (∼10%) of phosphorylation sites are phosphohistidine sites, to help enable a better understanding of the biological function of histidineosphorylation.

TL;DR: This study provided a clear trend that WcaJ tyrosine phosphorylation can regulate the biosynthesis of capsular polysaccharides and result in the pathogenicity of K. pneumoniae NTUH-K2044.

TL;DR: A robust protocol implementing methanol/chloroform protein precipitation and enzymatic digestion using benzonase, which degrades all forms of DNA and RNA, before IMAC-column loading is developed, resulting in a drastic increase of enrichment sensitivity, enabling the identification of around 17,000 unique phosphopeptides and 12,500 unambiguously localized phosphosites in human cell-lines from a single LC-MS/MS run.

TL;DR: TA-1, as a TLR2 agonist, could possibly be used as an adjuvant and could enhance cytokine release, which increases the immune response, and is dependent on MyD88/TIRAP.