M
Michael A. Charleston
Researcher at University of Tasmania
Publications - 113
Citations - 4686
Michael A. Charleston is an academic researcher from University of Tasmania. The author has contributed to research in topics: Phylogenetic tree & Population. The author has an hindex of 28, co-authored 104 publications receiving 4330 citations. Previous affiliations of Michael A. Charleston include University of Oxford & Australia Bioinformatics Resource.
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Journal ArticleDOI
The epidemic behavior of the hepatitis C virus.
Oliver G. Pybus,Michael A. Charleston,Sunetra Gupta,Andrew Rambaut,Edward C. Holmes,Paul H. Harvey +5 more
TL;DR: A new model of HCV spread is used to investigate the epidemic behavior of the virus and to estimate its basic reproductive number from gene sequence data to build a bridge between the disciplines of population genetics and mathematical epidemiology.
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From gene to organismal phylogeny: reconciled trees and the gene tree/species tree problem.
TL;DR: The use of reconciled trees to reconstruct the history of a gene tree with respect to a species tree is described and heuristic searches to find the species tree which yields the reconciled tree with the lowest cost are described.
Journal ArticleDOI
Trees within trees: phylogeny and historical associations
TL;DR: The association between two or more lineages over evolutionary time is a recurrent theme spanning several different fields within biology, from molecular evolution to coevolution and biogeography, raising the tantalizing prospect that each is a special case of a more general problem, and that a single analytical tool can be applied to all three kinds of association.
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Jungles: a new solution to the host/parasite phylogeny reconciliation problem
TL;DR: A new method of implicitly listing all the potentially optimal solutions to the problem of finding least-cost reconstructions of past host/parasite associations, by considering each hypothesised past association individually, in a structure I have termed a Jungle.
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Preferential host switching by primate lentiviruses can account for phylogenetic similarity with the primate phylogeny.
TL;DR: It is shown that, alternatively, frequent cross-species transmission of PLV, coupled with a tendency for more closely related primate species to exchange viruses "successfully," can result in apparent codivergence.