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Michael A. Cunningham
Researcher at University of Michigan
Publications - 3
Citations - 605
Michael A. Cunningham is an academic researcher from University of Michigan. The author has contributed to research in topics: Endoplasmic reticulum & Golgi apparatus. The author has an hindex of 3, co-authored 3 publications receiving 568 citations. Previous affiliations of Michael A. Cunningham include Mahidol University.
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Journal ArticleDOI
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
Bin Zhang,Michael A. Cunningham,William C. Nichols,John A. Bernat,Uri Seligsohn,Steven W. Pipe,John H. McVey,Ursula Schulte-Overberg,Norma B. de Bosch,Arlette Ruiz-Saez,Gilbert C. White,Edward G. D. Tuddenham,Randal J. Kaufman,David Ginsburg +13 more
TL;DR: It is shown that inactivating mutations in MCFD2 cause F5F8D with a phenotype indistinguishable from that caused by mutations in LMAN1, suggesting that theMCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Journal ArticleDOI
Bioengineering of coagulation factor VIII for improved secretion.
Hongzhi Z. Miao,Nongnuch Sirachainan,Nongnuch Sirachainan,Lisa Palmer,Lisa Palmer,Phillip Kucab,Phillip Kucab,Michael A. Cunningham,Michael A. Cunningham,Randal J. Kaufman,Randal J. Kaufman,Steven W. Pipe,Steven W. Pipe +12 more
TL;DR: FVIII bioengineered for improved secretion will significantly increase potential for success in gene therapy strategies for hemophilia A as well as improve recombinant FVIII production in cell culture manufacturing or transgenic animals.
Journal ArticleDOI
LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII.
Michael A. Cunningham,Steven W. Pipe,Bin Zhang,Hans Peter Hauri,David Ginsburg,Randal J. Kaufman +5 more
TL;DR: An interaction between LMAN1 and FVIII in vivo is demonstrated via high mannose‐containing asparagine‐linked oligosaccharides that are densely situated within the B domain of FV III, as well as protein–protein interactions.