David Ginsburg

TL;DR: In this article, the ADAMTS family of zinc metalloproteinase genes (ADAMTS13) was identified as the molecular mechanism responsible for TTP, and it was shown that the deficiency of ADADTS13 is the molecular mechanisms responsible for the development of TTP.

TL;DR: Data demonstrate a direct correlation between the genetically determined level of PAI-1 expression and the extent of collagen accumulation that follows inflammatory lung injury and strongly support the hypothesis that alterations in fibrinolytic activity influenceThe extent of pulmonary fibrosis that occurs after inflammatory injury.

TL;DR: Clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) is detected using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies to identify common deleted regions with genes previously associated with hematological cancers.

TL;DR: High-throughput analysis, using massively parallel signature sequencing (MPSS), of 230,000 tags from a DNase library generated from quiescent human CD4+ T cells identifies 14,190 clusters of sequences that group within close proximity to each other that represent valid DNase HS sites.

TL;DR: There are at least 580,000 persons with symptomatic VWD worldwide who could benefit from appropriate diagnosis followed by replacement or pharmacological therapy, and 80% of these persons live in the developing world.