M
Michael B. Elowitz
Researcher at California Institute of Technology
Publications - 122
Citations - 28898
Michael B. Elowitz is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 55, co-authored 110 publications receiving 26205 citations. Previous affiliations of Michael B. Elowitz include Howard Hughes Medical Institute & Rockefeller University.
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Stochastic Gene Expression in a Single Cell
TL;DR: This work constructed strains of Escherichia coli that enable detection of noise and discrimination between the two mechanisms by which it is generated and reveals how low intracellular copy numbers of molecules can fundamentally limit the precision of gene regulation.
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A synthetic oscillatory network of transcriptional regulators
TL;DR: This work used three transcriptional repressor systems that are not part of any natural biological clock to build an oscillating network, termed the repressilator, in Escherichia coli, which periodically induces the synthesis of green fluorescent protein as a readout of its state in individual cells.
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Intrinsic and extrinsic contributions to stochasticity in gene expression
TL;DR: It is shown how the total variation in the level of expression of a given gene can be decomposed into its intrinsic and extrinsic components and theoretically that simultaneous measurement of two identical genes per cell enables discrimination of these two types of noise.
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Functional roles for noise in genetic circuits
Avigdor Eldar,Michael B. Elowitz +1 more
TL;DR: Examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables are reviewed.
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Gene Regulation at the Single-Cell Level
TL;DR: It is found that protein production rates fluctuate over a time scale of about one cell cycle, while intrinsic noise decays rapidly, which can form a basis for quantitative modeling of natural gene circuits and for design of synthetic ones.