M
Michael B. Robinson
Researcher at Children's Hospital of Philadelphia
Publications - 149
Citations - 10682
Michael B. Robinson is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Glutamate receptor & Astrocyte. The author has an hindex of 57, co-authored 142 publications receiving 10204 citations. Previous affiliations of Michael B. Robinson include University of Minnesota & University of Pennsylvania.
Papers
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Journal ArticleDOI
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
TL;DR: There is recent evidence that upregulation of one of the glutamate transporters, GLT-1 (also called EAAT2), with beta-lactam antibiotics attenuates the damage observed in models of both acute and chronic neurodegenerative disorders.
Journal ArticleDOI
A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency.
Steven E. Raper,Marc Yudkoff,Narendra Chirmule,Guangping Gao,Fred Nunes,Ziv J. Haskal,Emma E. Furth,Kathleen J. Propert,Michael B. Robinson,Susan Magosin,Heather Simoes,Lisa Speicher,Joseph Hughes,John Tazelaar,Nelson A. Wivel,James M. Wilson,Mark L. Batshaw +16 more
TL;DR: The low levels of gene transfer detected in this trial suggest that at the doses tested, significant metabolic correction did not occur and restoration of enzyme activity in the liver should suffice to normalize metabolism.
Patent
Electron beam inspection system and method
Dan Meisburger,Alan D. Brodie,Curt H. Chadwick,Desai Anil,Hans Dohse,Emge Dennis,John D Greene,Ralph H. Johnson,Ling Ming-Yie,Mcmurtry John,Barry Becker,Paul Ray,Michael B. Robinson,Richard R. Simmons,Smith David E A,John C. Taylor,Lee H. Veneklasen,Dean Walters,Wieczorek Paul,Sam Wong,April Dutta,Lele Surendra,Rough Kirkwood,Henry Pearce-Percy,Jau Jack Y,Chun C. Lin,Hoi T. Nguyen,Oyang Yen-Jen,Hutcheson Timothy L,David J. Clark,Chung-Shih Pan,Chetana Bhaskar,Kirk Chris,Eric Munro +33 more
TL;DR: In this article, a substrate is mounted on an x-y stage to provide at least one degree of freedom while the substrate is being scanned by the charged particle beam, and an optical alignment system for initially aligning the substrate beneath the particle beam.
Journal ArticleDOI
Regulation of the Glial Na+-Dependent Glutamate Transporters by Cyclic AMP Analogs and Neurons
Brian D. Schlag,Joanna R. Vondrasek,Muhammad Munir,Avtandil Kalandadze,Olga Zelenaia,Jeffrey D. Rothstein,Michael B. Robinson +6 more
TL;DR: The studies suggest that GLT-1 and GLAST protein are regulated independently in astrocyte cultures and that a diffusible molecule secreted by neurons induces expression ofglial glutamate transporters inAstrocytes.
Journal ArticleDOI
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.
TL;DR: Comparison of the properties of NAALA dipeptidase to those of previously characterized enzymes suggests that this is a novel peptidase which may be involved in the synaptic degradation of N-acetyl-L-aspartyl- L-glutamate.