M
Michael Beil
Researcher at Hebrew University of Jerusalem
Publications - 108
Citations - 3628
Michael Beil is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 25, co-authored 77 publications receiving 3001 citations. Previous affiliations of Michael Beil include University of Ulm & Hadassah Medical Center.
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Journal ArticleDOI
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria
Subra Suresh,Joachim P. Spatz,J. P. Mills,Alexandre Micoulet,Ming Dao,Chwee Teck Lim,Michael Beil,T. Seufferlein +7 more
TL;DR: Comparing and contrast chemomechanical pathways whereby intracellular structural rearrangements lead to global changes in mechanical deformability of the cell, and examining the biochemical conditions mediating increases or decreases in modulus, and their implications for disease progression are compared.
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Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells
Michael Beil,Alexandre Micoulet,Götz von Wichert,Stephan Paschke,Paul Walther,M. Bishr Omary,Paul P. Van Veldhoven,Ulrike Gern,Elke Wolff-Hieber,Juliane Eggermann,Johannes Waltenberger,Guido Adler,Joachim P. Spatz,Thomas Seufferlein +13 more
TL;DR: It is shown that incubation of human epithelial tumour cells with SPC induces a perinuclear reorganization of intact keratin 8–18 filaments, which may facilitate biological phenomena that require a high degree of elasticity, such as squeezing of cells through membranous pores during metastasis.
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Detection and Segmentation of Cell Nuclei in Virtual Microscopy Images: A Minimum-Model Approach
Stephan Wienert,Daniel Heim,Kai Saeger,Albrecht Stenzinger,Michael Beil,Peter Hufnagl,Manfred Dietel,Carsten Denkert,Frederick Klauschen +8 more
TL;DR: A novel contour-based “minimum-model” cell detection and segmentation approach that uses minimal a priori information and detects contours independent of their shape and allows for an accurate segmentation of a broad spectrum of normal and disease-related morphological features without the requirement of prior training.
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The regulatory role of cell mechanics for migration of differentiating myeloid cells
Franziska Lautenschläger,Stephan Paschke,Stefan Schinkinger,Arlette Bruel,Michael Beil,Jochen Guck +5 more
TL;DR: The observations imply that the dynamical remodeling of cell shape required for tissue infiltration can be frustrated by stiffening the microtubular system, which suggests treatment options for pathologies relying on migration of cells, notably cancer metastasis.
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Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia
TL;DR: The current challenge is to unravel the molecular mechanisms underlying the regulation of the keratin cycle in relation to actin and microtubule networks and in the context of epithelial tissue function.