M
Michael D. Burkart
Researcher at University of California, San Diego
Publications - 280
Citations - 9481
Michael D. Burkart is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Acyl carrier protein & Polyketide. The author has an hindex of 44, co-authored 254 publications receiving 7833 citations. Previous affiliations of Michael D. Burkart include University of Kentucky & University of California, Los Angeles.
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Journal ArticleDOI
Selectfluor: mechanistic insight and applications.
TL;DR: The many applications of selectfluor are documented and possible mechanistic pathways for its reaction are discussed and this reagent is described as one of the most reactive electrophilic fluorinating reagents available, but it is also safe, nontoxic, and easy to handle.
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The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life
TL;DR: In this review, all current knowledge on this class of enzymes that post-translationally install a 4'-phosphopantetheine arm on various carrier proteins are discussed.
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Biomimetic synthesis and optimization of cyclic peptide antibiotics
TL;DR: It is shown that an isolated thioesterase can catalyse the cyclization of linear peptides immobilized on a solid-phase support modified with a biomimetic linker, offering the possibility of merging natural-product biosynthesis with combinatorial solid- phase chemistry.
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Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules.
TL;DR: BCP is shown to be a rapid and powerful approach for identifying the cellular pathway affected by antibacterial molecules and it is demonstrated that spirohexenolide A, a spirotetronate that is active against methicillin-resistant Staphylococcus aureus, rapidly collapses the proton motive force.
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Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology.
TL;DR: This review focuses on the recent discoveries and breakthroughs in the structural elucidation, molecular mechanism, and chemical biology underlying the discrete domains within NRPSs.