M
Michael D. Jones
Researcher at Imperial College London
Publications - 28
Citations - 3007
Michael D. Jones is an academic researcher from Imperial College London. The author has contributed to research in topics: Gene & Restriction map. The author has an hindex of 16, co-authored 28 publications receiving 2924 citations. Previous affiliations of Michael D. Jones include Hammersmith Hospital.
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Journal ArticleDOI
Simultaneous identification of bacterial virulence genes by negative selection
Michael Hensel,Jacqueline E. Shea,Colin Gleeson,Michael D. Jones,Emma Dalton,David W. Holden +5 more
TL;DR: An insertional mutagenesis system that uses transposons carrying unique DNA sequence tags resulted in the identification of new virulence genes, some of which are related to, but functionally distinct from, the inv/spa family of S. typhimurium.
Journal ArticleDOI
The DNA Sequence of Human Herpesvirus-6: Structure, Coding Content, and Genome Evolution
Ursula A. Gompels,John Nicholas,Glenda Lawrence,Glenda Lawrence,Michael D. Jones,Brian J. Thomson,Brian J. Thomson,M.E.D. Martin,Stacey Efstathiou,Stacey Efstathiou,M. Craxton,H.A. Macaulay +11 more
TL;DR: Comparisons of predicted amino acid sequences allowed the functions of many human herpesvirus-6 encoded proteins to be assigned and showed the closest relationship in overall number and similarity to human cytomegalovirus products, with approximately 67% homologous proteins as compared to the 21% identified in all herpesviruses.
Journal ArticleDOI
Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest
TL;DR: The technique of splicing by overlap extension by the polymerase chain reaction (SOE by PCR) is presented as an effective mechanism to splice DNA.
Journal ArticleDOI
Emergence of a New Highly Successful Acapsular Group A Streptococcus Clade of Genotype emm89 in the United Kingdom
Claire E. Turner,James Abbott,Theresa Lamagni,Matthew T. G. Holden,Matthew T. G. Holden,Sophia David,Michael D. Jones,Michael D. Jones,Laurence Game,Androulla Efstratiou,Shiranee Sriskandan +10 more
TL;DR: The genome remodeling in the new clade variant and the resultant altered phenotype appear to have conferred a selective advantage over other emm89 variants and may explain the changes observed in emm 89 GAS epidemiology.
Journal ArticleDOI
The genome of human herpesvirus 6: maps of unit-length and concatemeric genomes for nine restriction endonucleases.
M. E. D. Martin,Brian J. Thomson,R. W. Honess,M. A. Craxton,Ursula A. Gompels,M Y Liu,Edward Littler,John R. Arrand,I Teo,Michael D. Jones +9 more
TL;DR: The gross structure established here for the genome from the U1102 isolate of HHV-6 resembles closely that suggested by Pellett and his colleagues for the Z29 isolate and differs from that of the five previously characterized human herpesviruses.