U
Ursula A. Gompels
Researcher at University of London
Publications - 49
Citations - 2657
Ursula A. Gompels is an academic researcher from University of London. The author has contributed to research in topics: Gene & Human cytomegalovirus. The author has an hindex of 25, co-authored 48 publications receiving 2496 citations.
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Journal ArticleDOI
The DNA Sequence of Human Herpesvirus-6: Structure, Coding Content, and Genome Evolution
Ursula A. Gompels,John Nicholas,Glenda Lawrence,Glenda Lawrence,Michael D. Jones,Brian J. Thomson,Brian J. Thomson,M.E.D. Martin,Stacey Efstathiou,Stacey Efstathiou,M. Craxton,H.A. Macaulay +11 more
TL;DR: Comparisons of predicted amino acid sequences allowed the functions of many human herpesvirus-6 encoded proteins to be assigned and showed the closest relationship in overall number and similarity to human cytomegalovirus products, with approximately 67% homologous proteins as compared to the 21% identified in all herpesviruses.
Journal ArticleDOI
Classification of HHV-6A and HHV-6B as distinct viruses.
Dharam V. Ablashi,Henri Agut,Roberto Alvarez-Lafuente,Duncan A. Clark,Stephen Dewhurst,Dario DiLuca,Louis Flamand,Niza Frenkel,Robert C. Gallo,Ursula A. Gompels,Per Höllsberg,Steven Jacobson,Mario Luppi,Paolo Lusso,Mauro S. Malnati,Peter G. Medveczky,Yasuko Mori,Philip E. Pellett,Joshua C. Pritchett,Koichi Yamanishi,Tetsushi Yoshikawa +20 more
TL;DR: Several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHv-6B, which support the ICTV classification are outlined, are outlined.
Journal ArticleDOI
Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri.
TL;DR: Nine genes have been identified which encode amino acid sequences with greater similarity to proteins of the gammaherpesvirus Epstein-Barr virus than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simples virus type 1 or the betaherpevirus human cytomegalovirus.
Journal ArticleDOI
RANTES Binding and Down-Regulation by a Novel Human Herpesvirus-6 β Chemokine Receptor
Richard S. B. Milne,C Mattick,Linda K. Nicholson,Prema Devaraj,Antonio Alcami,Ursula A. Gompels +5 more
TL;DR: Regulation of RANTES levels may alter selective recruitment of circulating inflammatory cells that the virus can infect and thus could mediate the systemic spread of the virus from initial sites of infection in epithelia or modulate a protective inflammatory response to aid the spread of virus by immune evasion.
Journal ArticleDOI
The genome of human herpesvirus 6: maps of unit-length and concatemeric genomes for nine restriction endonucleases.
M. E. D. Martin,Brian J. Thomson,R. W. Honess,M. A. Craxton,Ursula A. Gompels,M Y Liu,Edward Littler,John R. Arrand,I Teo,Michael D. Jones +9 more
TL;DR: The gross structure established here for the genome from the U1102 isolate of HHV-6 resembles closely that suggested by Pellett and his colleagues for the Z29 isolate and differs from that of the five previously characterized human herpesviruses.