M
Michael D. Wyatt
Researcher at University of South Carolina
Publications - 82
Citations - 7089
Michael D. Wyatt is an academic researcher from University of South Carolina. The author has contributed to research in topics: DNA damage & Base excision repair. The author has an hindex of 31, co-authored 77 publications receiving 6484 citations. Previous affiliations of Michael D. Wyatt include Harvard University & Furman University.
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Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
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Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects.
Alaaldin M. Alkilany,Pratik K. Nagaria,Cole R. Hexel,Timothy J. Shaw,Catherine J. Murphy,Michael D. Wyatt +5 more
TL;DR: The results suggest that physiochemical surface properties of nanomaterials change substantially after coming into contact with biological media, and should be taken into consideration when examining the biological properties or environmental impact of nanoparticles.
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Methylating agents and DNA repair responses: methylated bases and sources of strand breaks
TL;DR: This review focuses on the DNA methyl damage caused by MMS and MNNG for each site of potential methylation to summarize what is known about the repair of such damage and the downstream responses and consequences if the damage is not repaired.
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GC base sequence recognition by oligo(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediaminetetraacetate-iron(II) footprinting studies
TL;DR: DNA binding properties of a series of imidazole-containing and C-terminus-modified analogues 4-7 of distamycin are described, and MPE footprinting studies on a GC-rich BamHI/SalI fragment of pBR322 provided unambiguous evidence for the GC sequence selectivity for some of these compounds.
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Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase
Bevin P. Engelward,Geert Weeda,Michael D. Wyatt,José L. M. Broekhof,Jan de Wit,Ingrid Donker,James M. Allan,Barry Gold,Jan H.J. Hoeijmakers,Leona D. Samson +9 more
TL;DR: Fibroblasts derived from Aag -/- mice are alkylation sensitive, indicating that Aag-/- mice may be similarly sensitive, and alkyladenine DNA glycosylase does not appear to be the major glycosyase for 8-oxoguanine repair.