M
Michael E. Burczynski
Researcher at University of Pennsylvania
Publications - 15
Citations - 2002
Michael E. Burczynski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Reductase & Aldo-keto reductase. The author has an hindex of 10, co-authored 15 publications receiving 1923 citations.
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Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione.
TL;DR: Human liver possesses multiple AKRs which contribute to PAH activation by catalyzing the NADP+-dependent oxidation of PAH trans-dihydrodiols to redox-active o-quinones.
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The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation.
TL;DR: The ability of this general metabolic enzyme to divert trans-dihydrodiols to o-quinones suggests that this pathway of PAH activation may be widespread in human tissues.
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Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)☆
Trevor M. Penning,Michael E. Burczynski,Joseph M. Jez,Hseuh Kung Lin,Haiching Ma,Margaret Moore,Kapila Ratnam,Nisha T. Palackal +7 more
TL;DR: It is predicted that AKR1C3 catalyzes an ordered bi bi mechanism, that the rate determining step is k(chem), and that an oxyanion prevails in the transition state, and steroidal-based inhibitors that compete with the steroid product would be desirable.
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Disposition and Biological Activity of Benzo[a]pyrene-7,8-dione. A Genotoxic Metabolite Generated by Dihydrodiol Dehydrogenase†,‡
TL;DR: The data indicate that DD suppresses the mutagenicity of (+/-)-anti-BPDE by producing BPQ, but in doing so a potent chemical nuclease is produced which causes extensive DNA fragmentation via the generation of ROS.
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Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).
TL;DR: The high catalytic efficiency of AKR 1A1 for potent proximate carcinogen trans-dihydrodiols and its presence in tissues that contain CYP1A1 and EH suggests that it plays an important role in this alternative pathway of PAH activation.