M
Michael E. Rosenfeld
Researcher at University of Washington
Publications - 145
Citations - 15237
Michael E. Rosenfeld is an academic researcher from University of Washington. The author has contributed to research in topics: Chlamydophila pneumoniae & Inflammation. The author has an hindex of 51, co-authored 145 publications receiving 14668 citations. Previous affiliations of Michael E. Rosenfeld include University of California, San Diego & University of California, Los Angeles.
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Journal ArticleDOI
Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.
Seppo Ylä-Herttuala,Wulf Palinski,Michael E. Rosenfeld,Sampath Parthasarathy,Thomas E. Carew,Susan Butler,Joseph L. Witztum,Daniel Steinberg +7 more
TL;DR: Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidatively modified in vitro.
Journal ArticleDOI
Low density lipoprotein undergoes oxidative modification in vivo
Wulf Palinski,Michael E. Rosenfeld,Seppo Ylä-Herttuala,Geoff C. Gurtner,Steve S. Socher,Susan Butler,Sampath Parthasarathy,Thomas E. Carew,Daniel Steinberg,Joseph L. Witztum +9 more
TL;DR: Three mutually supportive lines of evidence for oxidation of LDL in vivo are presented and autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera.
Journal ArticleDOI
Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.
Seppo Ylä-Herttuala,Beth A. Lipton,Michael E. Rosenfeld,Terttu Särkioja,Teizo Yoshimura,Edward J. Leonard,Joseph L. Witztum,Daniel Steinberg +7 more
TL;DR: It is concluded that MCP-1 is strongly expressed in a small subset of cells in macrophage-rich regions of human and rabbit atherosclerotic lesions and may play an important role in the ongoing recruitment of monocyte-macrophages into developing lesions in vivo.
Journal ArticleDOI
Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.
Wulf Palinski,Seppo Ylä-Herttuala,Michael E. Rosenfeld,Susan Butler,Steve A. Socher,Sampath Parthasarathy,Linda K. Curtiss,Joseph L. Witztum +7 more
TL;DR: These antibodies should prove useful in studying the role of oxidativelymodified lipoproteins as well as other oxidatively modified proteins in atherogenesis.
Journal ArticleDOI
Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.
TL;DR: Data from immunostain atherosclerotic lesions from Watanabe heritable hyperlipemic rabbits are interpreted as suggesting that in areas of lesions rich in macrophages, LDL is oxidized and taken up by the cells.