M
Michael Eichenberger
Researcher at Technische Universität Darmstadt
Publications - 8
Citations - 391
Michael Eichenberger is an academic researcher from Technische Universität Darmstadt. The author has contributed to research in topics: Saturated mutagenesis & Reductase. The author has an hindex of 5, co-authored 8 publications receiving 299 citations.
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Journal ArticleDOI
Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast
Mette L. Skjoedt,Tim Snoek,Kanchana Rueksomtawin Kildegaard,Dushica Arsovska,Michael Eichenberger,Tobias Justus Goedecke,Arun S. Rajkumar,Jie Zhang,Mette Kristensen,Beata Joanna Lehka,Solvej Siedler,Irina Borodina,Michael Krogh Jensen,Jay D. Keasling +13 more
TL;DR: The transplantation of prokaryotic transcriptional activators into the eukaryotic chassis illustrates the potential of a hitherto untapped biosensor resource useful for biotechnological applications.
Journal ArticleDOI
Metabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties
Michael Eichenberger,Beata Joanna Lehka,Christophe Folly,David Fischer,Stefan Martens,Ernesto Simon,Michael Naesby +6 more
TL;DR: De novo production of phloretin, the first committed dihydrochalcone, was achieved by co-expression of additional relevant pathway enzymes by exploiting substrate flexibility of enzymes involved in flavonoid biosynthesis.
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De novo biosynthesis of anthocyanins in Saccharomyces cerevisiae.
TL;DR: De novo biosynthesis of ACNs was shown for the first time in yeast and for theFirst time in a single microorganism and represents an important step towards sustainable industrial production of these highly relevant molecules in yeast.
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Improving heterologous production of phenylpropanoids in Saccharomyces cerevisiae by tackling an unwanted side reaction of Tsc13, an endogenous double-bond reductase.
Beata Joanna Lehka,Michael Eichenberger,Walden E. Bjørn-Yoshimoto,Katherina Garcia Vanegas,Nicolaas Buijs,Niels Bjerg Jensen,Jane Dannow Dyekjaer,Håvard Jenssen,Ernesto Simon,Michael Naesby +9 more
TL;DR: Phenylpropanoids, such as flavonoids and stilbenoids, are of great commercial interest, and their production in Saccharomyces cerevisiae is a very promising strategy, but each step of the process must be optimised.
Journal ArticleDOI
Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae
Katherina Garcia Vanegas,Arésu Bondrup Larsen,Michael Eichenberger,David Fischer,Uffe Hasbro Mortensen,Michael Naesby +5 more
TL;DR: Yeast is featured as a promising host for production of flavone C-glycosides, and it provides a set of tools and strains for identifying and studying CGTs and their mechanisms of C- glycosylation.