Michael Eschenberg

TL;DR: Motesanib diphosphate can induce partial responses in patients with advanced or metastatic differentiated thyroid cancer that is progressive and decrease in serum thyroglobulin concentration during treatment.

TL;DR: Although the objective response rate was low, a significant proportion of MTC patients (81%) achieved stable disease while receiving motesanib, and motesanIB trough concentrations were lower compared with differentiated thyroid cancer patients from the same study.

TL;DR: In this study, membrane vesicles harvested from BSEP-transfected insect cells were used to assess the activity of more than 200 benchmark compounds to thoroughly investigate the relationship between interference with BSEp function and liver injury, and suggest a relatively strong association between the pharmacological interference with bile salt export pump function and human hepatotoxicity.

TL;DR: Bone mass and strength increased progressively over 26 weeks of Scl-Ab treatment in adult OVX rats, and the early gains were accompanied by increased cortical and trabecular bone formation and reduced osteoclast activity, whereas later gains were attributed to residual endocortical and trABecular osteoblast stimulation and persistently low osteOClast activity.

TL;DR: The first application of oscillatory rheology is reported to study phase behavior of IgG2 in a sucrose-containing formulation and its correspondence with physical stability not explained by glass transition, providing a mechanism and data suggesting that protein instability occurs at the ice/water interface.