Michael Golden

TL;DR: The key feature of RDP4 that differentiates it from other recombination detection tools is its flexibility, which can be run either in fully automated mode from the command line interface or with a graphically rich user interface that enables detailed exploration of both individual recombination events and overall recombination patterns.

TL;DR: The ecological, biochemical and selective factors underlying patterns of genetic exchange detectable amongst the ssDNA viruses are discussed and how these should all be considered when assessing the adaptive value of recombination during ssDNA virus evolution is discussed.

TL;DR: High-throughput, single-nucleotide resolution information is used to generate and functionally test data-driven structural models for three diverse HCV RNA genomes and identified, de novo, multiple regions of conserved RNA structure, including all previously characterized cis-acting regulatory elements and also multiple novel structures required for optimal viral fitness.

TL;DR: It is demonstrated how this insight, taken together with phylogenetic analyses of predicted coat protein and replication associated protein amino acid sequences indicate that the most recent common ancestor of the geminiviruses was likely a dicot-infecting virus that expressed its Rep from a spliced complementary strand transcript.

TL;DR: The membrane-distal regions of NiV-F and the F glycoprotein from closely related Hendra virus are revealed as attractive targets for antiviral and vaccine development and are targeted by the antibody-mediated immune response across henipaviruses.