M
Michael Hauptmann
Researcher at Netherlands Cancer Institute
Publications - 210
Citations - 11957
Michael Hauptmann is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 54, co-authored 203 publications receiving 10189 citations. Previous affiliations of Michael Hauptmann include National Institutes of Health & United States Department of Health and Human Services.
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Journal ArticleDOI
Confounding of the association between radiation exposure from CT scans and risk of leukemia and brain tumors by cancer susceptibility syndromes.
Johanna M. Meulepas,Cécile M. Ronckers,Johannes H. M. Merks,Michel E. Weijerman,Jay H. Lubin,Michael Hauptmann +5 more
TL;DR: Assessment indicates that associations with radiation exposure from pediatric CT scans and leukemia or brain tumors reported in previous studies are unlikely to be substantially confounded by unmeasured CSS.
Journal ArticleDOI
CYP2C19*2 predicts substantial tamoxifen benefit in postmenopausal breast cancer patients randomized between adjuvant tamoxifen and no systemic treatment
Karin Beelen,Mark Opdam,Tesa M. Severson,Rutger H. T. Koornstra,Andrew D. Vincent,Michael Hauptmann,R.H.N. van Schaik,Emjj Berns,Jan B. Vermorken,P. J. Van Diest,Sabine C. Linn +10 more
TL;DR: Breast cancer patients carrying at least one CYP2C19*2 allele have an adverse prognosis in the absence of adjuvant systemic treatment, which can be substantially improved by adjUvant tamoxifen treatment.
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Platform comparisons for identification of breast cancers with a BRCA-like copy number profile
Philip C. Schouten,Ewald van Dyk,Linde M. Braaf,Lennart Mulder,Esther H. Lips,Jorma J. de Ronde,Laura Holtman,Jelle Wesseling,Michael Hauptmann,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Sabine C. Linn,Petra M. Nederlof +12 more
TL;DR: It is shown that breast cancer patients with BRCA-like tumour aCGH profiles benefit substantially from platinum-based chemotherapy, potentially due to their inability to repair DNA double strand breaks (DSB), providing a further important clinical application for the classifiers.
Journal ArticleDOI
Colorectal adenomas and cancers after childhood cancer treatment: A DCOG-LATER record linkage study
Jop C Teepen,Judith L. Kok,Flora E. van Leeuwen,Wim J. E. Tissing,Wil V. Dolsma,Helena J.H. van der Pal,Jacqueline J. Loonen,Dorine Bresters,Birgitta Versluys,Marry M. van den Heuvel-Eibrink,Eline van Dulmen-den Broeder,Marleen H. van den Berg,Margriet van der Heiden-van der Loo,Michael Hauptmann,Marjolijn C.J. Jongmans,Lucy I. H. Overbeek,Marc J. van de Vijver,Leontien C. M. Kremer,Cécile M. Ronckers +18 more
TL;DR: Evidence is provided for excess risk of colorectal adenomas and CRCs among childhood cancer survivors and Hepatoblastoma and family history of early-onset CRC were confirmed as strong risk factors.
Journal ArticleDOI
Radiotherapy in laryngeal carcinoma: Can a panel of 13 markers predict response?
Maarten A. Wildeman,Johan H. Gibcus,Michael Hauptmann,Adrian C. Begg,Marie Louise F. Van Velthuysen,Frank J. P. Hoebers,Mirjam F. Mastik,Ed Schuuring,Jacqueline E. van der Wal,Michiel W. M. van den Brekel +9 more
TL;DR: To find biomarkers associated with response to radiotherapy in laryngeal cancer that can be used together with clinical parameters to improve outcome prediction.