M
Marry M. van den Heuvel-Eibrink
Researcher at Boston Children's Hospital
Publications - 378
Citations - 10782
Marry M. van den Heuvel-Eibrink is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 49, co-authored 314 publications receiving 8270 citations. Previous affiliations of Marry M. van den Heuvel-Eibrink include University Medical Center Groningen & Children's Oncology Group.
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Journal ArticleDOI
Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
Ursula Creutzig,Marry M. van den Heuvel-Eibrink,Brenda Gibson,Michael Dworzak,Souichi Adachi,Eveline S. J. M. de Bont,Jochen Harbott,Henrik Hasle,Donna L. Johnston,Akitoshi Kinoshita,Thomas Lehrnbecher,Guy Leverger,Ester Mejstrikova,Soheil Meshinchi,Andrea Pession,Susana C. Raimondi,Lillian Sung,Jan Stary,Christian M. Zwaan,Gertjan J.L. Kaspers,Dirk Reinhardt +20 more
TL;DR: In this article, the authors discuss differences between childhood and adult acute myeloid leukemia (AML) and highlight recommendations that are specific to children, as well as the particular relevance of new diagnostic and prognostic molecular markers in pediatric AML.
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Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.
Brian V. Balgobind,Susana C. Raimondi,Susana C. Raimondi,Jochen Harbott,Martin Zimmermann,Todd A. Alonzo,Anne Auvrignon,H. Berna Beverloo,Myron Chang,Ursula Creutzig,Michael Dworzak,Erik Forestier,Brenda Gibson,Henrik Hasle,Christine J. Harrison,Nyla A. Heerema,Nyla A. Heerema,Gertjan J.L. Kaspers,Anna Leszl,Nathalia Litvinko,Luca Lo Nigro,Akira Morimoto,Christine Perot,Rob Pieters,Dirk Reinhardt,Jeffrey E. Rubnitz,Franklin O. Smith,Franklin O. Smith,Jan Stary,Irina Stasevich,Sabine Strehl,Takashi Taga,Daisuke Tomizawa,David Webb,Zuzana Zemanova,C. Michel Zwaan,Marry M. van den Heuvel-Eibrink +36 more
TL;DR: Large differences in outcome within 11q23/MLL-rearranged pediatric AML and novel subgroups based on translocation partners that independently predict clinical outcome are identified.
Journal ArticleDOI
Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial
Franco Locatelli,Peter Nöllke,Marco Zecca,E T Korthof,Edoardo Lanino,Christina Peters,Andrea Pession,Hartmut Kabisch,Cornelio Uderzo,Carmen Bonfim,Peter Bader,Dagmar Dilloo,Jan Stary,Alexandra Fischer,T Revesz,Monika Führer,Henrik Hasle,M. Trebo,Marry M. van den Heuvel-Eibrink,Susanna Fenu,Brigitte Strahm,Giovanna Giorgiani,Mario Regazzi Bonora,Ulrich Duffner,Charlotte M. Niemeyer +24 more
TL;DR: Outcome of UD-HSCT recipients is comparable to that of children receiving transplants from an HLA-identical sibling, and disease recurrence remains the major cause of treatment failure.
Journal ArticleDOI
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
Mignon L. Loh,Debbie S Sakai,Christian Flotho,Michelle Kang,Manfred Fliegauf,Sophie Archambeault,Charles G. Mullighan,Leslie Chen,Eva Bergstraesser,Carlos E. Bueso-Ramos,Peter D. Emanuel,Henrik Hasle,Jean Pierre Issa,Marry M. van den Heuvel-Eibrink,Franco Locatelli,Jan Starý,Monica Trebo,Marcin W. Wlodarski,Marco Zecca,Kevin Shannon,Charlotte M. Niemeyer +20 more
TL;DR: The exclusivity of CBL mutations with respect to other Ras pathway-associated mutations indicates that CBL may have a role in deregulating this key pathway in JMML.
Journal ArticleDOI
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern.
Iris H.I.M. Hollink,Marry M. van den Heuvel-Eibrink,Susan T.C.J.M. Arentsen-Peters,Marta Pratcorona,Saman Abbas,Jenny E. Kuipers,Janneke F. van Galen,H. Berna Beverloo,Edwin Sonneveld,Gertjan J.L. Kaspers,Jan Trka,André Baruchel,Martin Zimmermann,Ursula Creutzig,Dirk Reinhardt,Rob Pieters,Peter J. M. Valk,C. Michel Zwaan +17 more
TL;DR: High-resolution genome-wide copy number analyses revealed cryptic NUP98/NSD1 translocations in 3 of 92 cytogenetically normal (CN)-AML cases, identifying a previously unrecognized group of young AML patients, with distinct characteristics and dismal prognosis, for whom new treatment strategies are urgently needed.