M
Michael Hennig
Researcher at Hoffmann-La Roche
Publications - 106
Citations - 5957
Michael Hennig is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Binding site & Carnitine. The author has an hindex of 39, co-authored 102 publications receiving 5451 citations. Previous affiliations of Michael Hennig include University of Cologne & University of Göttingen.
Papers
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Journal ArticleDOI
Crystallization and preliminary X-ray analysis of wild-type and K272A mutant glutamate 1-semialdehyde aminotransferase from Synechococcus.
TL;DR: Crystals of the pyridoxal-5'-phosphate dependent enzyme glutamate-1-semialdehyde aminotransferase (EC 5.4.8) from Synechococcus have been grown from polyethylene glycol solutions.
Journal ArticleDOI
Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2
Stefanie K. Fehler,Gerald Pratsch,Walter Huber,Alain Gast,Remo Hochstrasser,Michael Hennig,Markus R. Heinrich +6 more
TL;DR: In this article, 3-Aryltyramines were prepared in one single step from tyramine and various arenediazonium salts by radical arylation.
Posted ContentDOI
Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation
Mathieu Botte,Alexander K. C. Ulrich,Ricardo Adaixo,David Gnutt,Andreas Brockmann,Denis Bucher,Mohamed Chami,Nicolas Bocquet,Ulrich Ebbinghaus-Kintscher,Vera Puetter,Andreas Becker,Ursula Egner,Henning Stahlberg,Michael Hennig,Simon Holton +14 more
TL;DR: The novel cryo-EM structure of the hTRPV4 determined in the presence of the archetypical phorbol acid agonist, 4α-PDD is reported, representing the first structural information of hTRpV4 in a ligand-induced open conformation.
Patent
Pseudopolymorphic forms of carvedilol
Andre Bubendorf,Gabel Rolf-Dieter,Michael Hennig,Krimmer Siegfried,Guenter Neugebauer,Preis Walter,Alexander Wirl +6 more
TL;DR: In this article, the present invention is concerned with pseudopolymorphic forms of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole (carvedilol) or of optically active forms or pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them.
Patent
Polymorph of {6,7-bis(2-methoxy-ethoxy)-quinazolin-4-yl}-(3e)
TL;DR: In this article, a novel polymorph of [6,7-Bis(2methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride was proposed.