Walter Huber

TL;DR: A generic model for the prediction of drug association constants to HSA is reported, which uses a pharmacophoric similarity concept and partial least square analysis (PLS) to construct a quantitative structure-activity relationship.

TL;DR: This work combines as key techniques an in silico screening for potential low molecular weight inhibitors, a biased high throughput DNA gyrase screen, validation of the screening hits by biophysical methods, and a 3D guided optimization process.

TL;DR: It is demonstrated that gantenerumab preferentially interacts with aggregated Aβ in the brain and lowers amyloid-β by eliciting effector cell-mediated clearance.

TL;DR: An assessment of the activities of four selected compounds containing ethyl, propyl, and isopropyl side chains that retain activity against chloroquine-resistant isolates of Plasmodium falciparum malaria and the formation of N-dealkylated metabolites of these compounds.

TL;DR: In this paper, the fundamental physics of electron spin resonance are discussed, including spin density, spin population, spin polarization, and spin delocalization, as well as the relationship between spin density and spin population.